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There is strong evidence that class I MHC-restricted parasite-specific CD8+ CTL protect cattle against the protozoan parasite Theileria parva. As part of an effort to develop a subunit vaccine for the induction of these responses, we have investigated the factors involved in the generation of T. ...


Taracha, E.L.N.Awino, EliasMcKeever, Declan J.[Distinct CD4 + T cell helper requirements in Theileria parva-immune and -naive bovine CTL precursors]Distinct CD4 + T cell helper requirements in Theileria parva-immune and -naive bovine CTL precursors
Howard, C.J.Sopp, P.Parsons, K.R.McKeever, Declan J.Taracha, E.L.N.Jones, B.V.MacHugh, Niall D.Morrison, W. Ivan[Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45]Distinction of naive and memory BoCD4 lymphocytes in calves with a monoclonal antibody, CC76, to a restricted determinant of the bovine leukocyte-common antigen, CD45

The importance of T-cell-mediate immune responses in the control of intracellular protozoan parasites is now well established 1-3. The killing of parasitized cells by T cells and cytokine-mediated effects on growth and viability of the intracellular parasites have both been implicated as effector...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Contribution of T-cell responses to immunity and pathogenesis in infection with Theileria parva]Contribution of T-cell responses to immunity and pathogenesis in infection with Theileria parva
McKeever, Declan J.Taracha, E.L.N.Innes, E.L.MacHugh, Niall D.Awino, EliasGoddeeris, B.M.Morrison, W. Ivan[Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph]Adoptive transfer of immunity to Theileria parva in the CD8+ fraction of responding effluent lymph

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