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Cattle immunised with a recombinant form of p67, the major surface antigen of Theilleria parva sporozoites, have been shown to be protected against parasite challenge. In an attempt to simplify the immunisation procedure live attenuated Salmonella strains expressing p67 have been constructed and ...


Heussler, V.T.Taracha, E.L.N.Musoke, A.J.Duchateau, L.McKeever, Declan J.[Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva]Immunisation with live attenuated Salmonella dublin expressing a sporozoite protein confers partial protection against Theileria parva

Enhancement of the induction of cytotoxic T-cell responses by immunostimulatory CpG oligodeoxynucleotides has been described in humans and mouse models. The present study attempted to address whether CpG has a similar effect in cattle. Immunisation of cattle with a recombinant form of the polymor...


Graham, S.P.Saya, R.Awino, EliasNgugi, D.Nyanjui, J.K.Hecker, R.Taracha, E.L.N.Nene, Vishvanath[Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva]Immunostimulatory CpG oligodeoxynucleotides enhance the induction of bovine CD4+ cytotoxic T-lymphocyte responses against the polymorphic immunodominant molecule of the protozoan parasite Theileria parva

The parasite strain specificity of CTL responses to Theileria parva varies among cattle immunized with the same parasite stock. We have investigated the influence of class I MHC on the strain specificity of CTL responses to T. parva in 19 cattle of defined class I phenotype immunized with either ...


Taracha, E.L.N.Goddeeris, B.M.Teale, A.J.Kemp, Stephen J.Morrison, W. Ivan[Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance]Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance

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