East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...
Akoolo, L.
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Pelle, Roger
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Saya, R.
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Awino, Elias
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Nyanjui, J.
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Taracha, E.L.N.
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Kanyari, P.
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Mwangi, D.M.
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Graham, S.P.
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[Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle]
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Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle
Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...
McKeever, Declan J.
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Taracha, E.L.N.
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Morrison, W. Ivan
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Musoke, A.J.
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Morzaria, S.P.
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[Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies]
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Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies
Heterologous priming-boosting vaccination regimens involving priming with plasmid DNA antigen constructs and inoculating (boosting) with the same recombinant antigen expressed in replication-attenuated poxviruses have recently been demonstrated to induce immunity, based on CD4(+)- and CD8(+)-T-c...
Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...
Morrison, W. Ivan
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Taracha, E.L.N.
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McKeever, Declan J.
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[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]
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Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite