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East Coast fever (ECF) is a highly fatal lymphoproliferative disease of cattle caused by Theileria parva, a tick-borne intracellular apicomplexan parasite. Parasite antigens that are targets of protective cytotoxic T lymphocyte (CTL) responses are required to formulate a sub-unit vaccine against ...


Akoolo, L.Pelle, RogerSaya, R.Awino, EliasNyanjui, J.Taracha, E.L.N.Kanyari, P.Mwangi, D.M.Graham, S.P.[Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle]Evaluation of the recognition of Theileria parva vaccine candidate antigens by cytotoxic T lymphocytes from Zebu cattle

Theileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understandin...


McKeever, Declan J.Taracha, E.L.N.Morrison, W. IvanMusoke, A.J.Morzaria, S.P.[Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies]Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies

Heterologous priming-boosting vaccination regimens involving priming with plasmid DNA antigen constructs and inoculating (boosting) with the same recombinant antigen expressed in replication-attenuated poxviruses have recently been demonstrated to induce immunity, based on CD4(+)- and CD8(+)-T-c...


Taracha, E.L.N.Bishop, Richard P.Musoke, A.J.Hill, A.V.S.Gilbert, S.C.[Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses]Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses

Studies of the immune responses of cattle to Theileria parva have provided evidence that immunity to the parasite can operate at two levels, namely the sporozoite and the schizont-infected lymphoblast. Antibodies that neutralize the infectivity of sporozoites have been detected in the serum of hy...


Morrison, W. IvanTaracha, E.L.N.McKeever, Declan J.[Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite]Theileriosis: Progress towards vaccine development through understanding immune responses to the parasite

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