Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the de...
Williams, D.J.L.
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Taylor, K.
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Wilkie, B.
,
Gichuki, B.
,
Authié, E.
,
[Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle]
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Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle
The mechanisms whereby trypanotolerant N'Dama cattle control infection with Trypanosoma congolense are unknown. Previous studies have suggested that the monocytes of N'Dama cattle are more highly activated during infection than those of trypanosus ceptible Boan cattle. However, we have recently r...
Taylor, K.
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Mertens, B.
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Lutje, V.
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Saya, R.
,
[Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10]
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Trypanosoma congolense infection of trypanotolerant N'Dama (Bos taurus) cattle is associated with decreased secretion of nitric oxide by interferon-gamma-activated monocytes and increased transcription of interleukin-10
African trypanosomes are important pathogens of both humans and livestock. We investigated the association of cytokine responses with disease susceptibility in Trypanosoma congolense-infected cattle. Changes in interleukin (IL)-1 beta, IL-2, IL-4, IL-5, IL-6, IL-12 p40, tumor necrosis factor-alph...
Mertens, B.
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Taylor, K.
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Muriuki, C.
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Rocchi, M.
,
[Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4]
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Cytokine mRNA profiles in trypanotolerant and trypanosusceptible cattle infected with the protozoan parasite trypanosoma congolense: Protective role for interleukin-4
It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exp...
Williams, D.J.L.
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Taylor, K.
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Newson, J.
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Gichuki, B.
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Naessens, Jan
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[The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance]
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The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance
Infection with African trypanosomes causes the diseases sleeping sickness in humans and nagana in cattle in sub-Saharan Africa. Suppression of cellular immune responses is a feature of trypanosomiasis in bovine, human, and murine hosts. Some aspects of immunosuppression in the murine model are me...
Taylor, K.
,
Lutje, V.
,
Mertens, B.
,
[Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression]
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Nitric Oxide synthesis is depressed in Bos indicus cattle infected with Trypanosoma congolense and Trypanosoma vivax and does not mediate T-cell suppression
The Development of vaccine against the African trypanosomiasis passes through the identification process of invariant component. This process targets the prevention of infection or diseases related to it. Immunity suppression in almost a universal feature of infection and represents probably an e...
Taylor, K.
,
Mertens, B.
,
Rocchi, M.
,
Elson, L.
,
[Immune suppression during bovine trypanosomosis]
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Immune suppression during bovine trypanosomosis
The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a parti...
Williams, D.J.L.
,
Taylor, K.
,
Newson, J.
,
Naessens, Jan
,
Authié, E.
,
[Protective and inappropriate antibody responses in trypanosome-infected cattle]
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Protective and inappropriate antibody responses in trypanosome-infected cattle