Infection of livestock with African trypanosomes leads to haematological changes such as anaemia and pancytopenia and to immune defects, including suppression of T-cell responsiveness and an excessive increase in the CD5+ B-cell population in blood and spleen. It has been shown that certain breed...
Mertens, B.
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Gaidulis, L.
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Mwangi, S.
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Suliman, H.
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Taylor, K.A.
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[Development of bovine-specific cytokine reagents at ILRAD]
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Development of bovine-specific cytokine reagents at ILRAD
African trypansosomes are tsetse-transmitted parasites of chief importance in causing disease in livestock in regions of sub-Saharan Africa. Previous studies have demonstrated that certain breeds of cattle are relatively resistant to infection with trypanosomes, and others are more susceptible. B...
Haas, K.M.
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Taylor, K.A.
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MacHugh, Niall D.
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Kreeger, J.M.
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Estes, D.M.
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[Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection]
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Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection
Memory T- and B-cell responses to trypanosome antigens were measured in peripheral blood mononuclear cells, spleen and lymph node cells obtained from 4 trypanotolerant N'Dama cattle which had been exposed to 6 experimental infections with Trypanosoma congolense. These cattle were treated with try...
Lutje, V.
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Taylor, K.A.
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Boulange, A.F.
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Authié, E.
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[Trypanosoma congolense: Tissue distribution of long-term T- and B-cell responses in cattle]
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Trypanosoma congolense: Tissue distribution of long-term T- and B-cell responses in cattle
Trypanosomosis in domestic livestock negatively impacts food production and economic growth in many parts of the world, particularly in sub-Saharan Africa. Current methods of control are inadequate to prevent the enormous annual socio-economic losses resulting from this disease. Hope for a vaccin...
Taylor, K.A.
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[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]
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Immune responses of cattle to African trypanosomes: Protective or pathogenic?
Trypanotolerance involves an ability to both control trypanosome multiplication and resist the pathogenic effects of trypanosome infection. Studies in the African Trypanotolerant Livestock Network and elsewhere have shown that the latter capacity is more closely correlated than the former to the ...
Analysis of serum antibody responses in cattle experimentally infected with Trypanosoma congolense suggested that antibody responses of trypanosusceptible Boran cattle are less efficient in isotype switching and affinity maturation than those of trypanotolerant N'Dama cattle. High levels of polys...