Trypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic secur...
Taylor, K.A.
,
Mertens, B.
,
[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]
,
Immune responses of cattle to African trypanosomes: Protective or pathogenic?
Trypanosomosis in domestic livestock negatively impacts food production and economic growth in many parts of the world, particularly in sub-Saharan Africa. Current methods of control are inadequate to prevent the enormous annual socio-economic losses resulting from this disease. Hope for a vaccin...
Taylor, K.A.
,
[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]
,
Immune responses of cattle to African trypanosomes: Protective or pathogenic?
Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...
Taylor, K.A.
,
Lutje, V.
,
Kennedy, D.
,
Authié, E.
,
Boulange, A.F.
,
Logan-Henfrey, L.L.
,
Gichuki, B.
,
Gettinby, G.
,
[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]
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Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle
A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...
Lutje, V.
,
Taylor, K.A.
,
Kennedy, D.
,
Authié, E.
,
Boulange, A.F.
,
Gettinby, G.
,
[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]
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Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection
Analysis of serum antibody responses in cattle experimentally infected with Trypanosoma congolense suggested that antibody responses of trypanosusceptible Boran cattle are less efficient in isotype switching and affinity maturation than those of trypanotolerant N'Dama cattle. High levels of polys...