African trypansosomes are tsetse-transmitted parasites of chief importance in causing disease in livestock in regions of sub-Saharan Africa. Previous studies have demonstrated that certain breeds of cattle are relatively resistant to infection with trypanosomes, and others are more susceptible. B...
Haas, K.M.
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Taylor, K.A.
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MacHugh, Niall D.
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Kreeger, J.M.
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Estes, D.M.
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[Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection]
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Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection
Memory T- and B-cell responses to trypanosome antigens were measured in peripheral blood mononuclear cells, spleen and lymph node cells obtained from 4 trypanotolerant N'Dama cattle which had been exposed to 6 experimental infections with Trypanosoma congolense. These cattle were treated with try...
Lutje, V.
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Taylor, K.A.
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Boulange, A.F.
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Authié, E.
,
[Trypanosoma congolense: Tissue distribution of long-term T- and B-cell responses in cattle]
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Trypanosoma congolense: Tissue distribution of long-term T- and B-cell responses in cattle
Taylor, K.A.
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Gichuki, B.
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Lutje, V.
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Naessens, Jan
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Williams, D.J.L.
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[In vitro activation and detection of antibody-secreting cells from Trypanosoma congolense-infected cattle]
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In vitro activation and detection of antibody-secreting cells from Trypanosoma congolense-infected cattle
Trypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic secur...
Taylor, K.A.
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Mertens, B.
,
[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]
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Immune responses of cattle to African trypanosomes: Protective or pathogenic?
Trypanosomosis in domestic livestock negatively impacts food production and economic growth in many parts of the world, particularly in sub-Saharan Africa. Current methods of control are inadequate to prevent the enormous annual socio-economic losses resulting from this disease. Hope for a vaccin...
Taylor, K.A.
,
[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]
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Immune responses of cattle to African trypanosomes: Protective or pathogenic?
Trypanosomiasis is a serious constraint to livestock production in sub-Saharan Africa. Some breeds of cattle are genetically more resistant to the pathogenic effects of trypanosome infection. We measured B-cell activation and the quantity and isotype of antibody produced at the cellular level in ...
Taylor, K.A.
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Lutje, V.
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Kennedy, D.
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Authié, E.
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Boulange, A.F.
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Logan-Henfrey, L.L.
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Gichuki, B.
,
Gettinby, G.
,
[Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle]
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Trypanosoma congolense: B-Lymphocyte responses differ between trypanotolerant and trypanosusceptible cattle
A comparison of T-cell-mediated immune responses in trypanotolerant N'Dama and susceptible Boran cattle during primary infection with tsetse-transmitted Trypanosoma congolense was conducted to assess whether different patterns of T-cell activation occurred during trypanosome infection. Proliferat...
Lutje, V.
,
Taylor, K.A.
,
Kennedy, D.
,
Authié, E.
,
Boulange, A.F.
,
Gettinby, G.
,
[Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection]
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Trypanosoma congolense: A comparison of T-cell-mediated responses in lymph nodes of trypanotolerant and trypanosusceptible cattle during primary infection