Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...
Naessens, Jan
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Teale, A.J.
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Sileghem, M.R.
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[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]
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Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...
The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin)and Tnfb (lymphotoxin-alpha) (Semon et al. 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC)region. Tnfa and soluble lymphotoxin alp...
Iraqi, F.A.
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Teale, A.J.
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[Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice]
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Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice