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We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance
Autor: Teale, A.J.

Presents reports of the gene mapping laboratories and of those laboratories and groups concerned directly with trypanotolerance research and summarises the final round table discussion, and the workshop's recommendations concerning genome mapping development and the production and use of trypanot...


Teale, A.J.[Bovine genome. Mapping and trypanotolerance. Proceedings of a workshop]Bovine genome. Mapping and trypanotolerance. Proceedings of a workshop
Naessens, JanNewson, J.Bensaid, A.Teale, A.J.Magondu, J.Black, S.J.[De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle]De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle

To optimize designs to implement marker-assisted introgression programs aiming to introgress three unlinked quantitative trait loci (QTL), the present paper studies different alternatives versus a traditional backcross or intercross phase. Four alternative backcross strategies appear to be more a...


Koudande, O.D.Iraqi, F.A.Thomson, P.C.Teale, A.J.Arendonk, Johan A.M. van[Strategies to optimize marker-assisted introgression of multiple unlinked QTL]Strategies to optimize marker-assisted introgression of multiple unlinked QTL
Pepin, L.Winjgaard, P.Lehrun, D.MacHugh, Niall D.Teale, A.J.Maillard, J.C.Clevers, H.Bensaid, A.M.[Description of a new bovine multigene family encoding for markers of differentiation of y/d T-cells]Description of a new bovine multigene family encoding for markers of differentiation of y/d T-cells

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin)and Tnfb (lymphotoxin-alpha) (Semon et al. 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC)region. Tnfa and soluble lymphotoxin alp...


Iraqi, F.A.Teale, A.J.[Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice]Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice

The applicability of bovine autosomal micro-satellite markers for population genetic studies on African buffalo was investigated. A total of 168 microsatellite markers were tested for PCR amplification on a test panel of seven African buffalo. Amplification was observed for 139 markers (83 percen...


Hooft, W.F. vanHanotte, Olivier H.Wenink, P.W.Groen, A.F.Sugimoto, Y.Prins, H.H.T.Teale, A.J.[Applicability of bovine microsatellite markers for population genetic studies on African buffalo (Syncerus caffer)]Applicability of bovine microsatellite markers for population genetic studies on African buffalo (Syncerus caffer)

A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...


Teale, A.J.Agaba, MorrisClapcott, S.J.Gelhaus, A.Haley, C.Psifidis, A.Horstmann, R.Iraqui, F.Kemp, Stephen J.Nilsson, P.Schwerin, M.Sekikawa, K.Soller, M.Sugimoto, Y.Womack, J.[Resistance to trypanosomosis: Of markers, genes and mechanisms]Resistance to trypanosomosis: Of markers, genes and mechanisms
Hanotte, Olivier H.Verjee, Y.Ochieng, O.Teale, A.J.Rege, J.E.O.[Usefulness of cattle microsatellite markers for amplification of polymorphic loci in Asian bovidae]Usefulness of cattle microsatellite markers for amplification of polymorphic loci in Asian bovidae

Several West African Bos taurus cattle breeds show a remarkable ability to survive and be productive in the face of a trypanosome challenge which would quickly kill susceptible cattle. This phenomenon, termed trypanotolerance, offers a sustainable approach to improving cattle productivity in the...


Kemp, Stephen J.Teale, A.J.[Markers for mapping trypanotolerance genes]Markers for mapping trypanotolerance genes

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