Human chromosome (Chr) 18(HSA 18) contains approximately 85 million base pains of DNA. Thirty genes and pseudogenes have been mapped to HSA 18 by somatic cell genetics or in situ hybridization. Two bovine genes - Yamaguchi sacroma viral oncogene homology 1 (YESI) and desmocollin type 1 (DSC1) - h...
Agaba, Morris
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Kemp, Stephen J.
,
Barendse, W.
,
Teale, A.J.
,
[Comparative mapping in cattle of genes located on human chromosome 18]
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Comparative mapping in cattle of genes located on human chromosome 18
A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...
Nilsson, P.H.
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Kang'a, S.
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Rottengatter, K.
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Suedbeck, U.
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Iraqui, F.
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Mwakaya, J.
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Mwangi, D.
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Womack, J.E.
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Goldammer, T.
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Schwerin, M.
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Bradley, D.
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Agaba, Morris
,
Sugimoto, K.
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Gelhaus, A.
,
Horstmann, R.
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Teale, A.J.
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Kemp, Stephen J.
,
Hanotte, Olivier H.
,
[Radiation hybrid maps of candidate trypanotolerance regions in cattle]
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Radiation hybrid maps of candidate trypanotolerance regions in cattle
We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...
Park, S.D.E.
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Adomefa, K.
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Dao, B.
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Hanotte, Olivier H.
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Kemp, Stephen J.
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Sow, R.S.
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Teale, A.J.
,
Bradley, D.G.
,
[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]
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Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance
Thymic-derived lymphocytes (T cells) recognize and respond to antigens through the mediation of the T-cell receptor complex. Here we report polymorphism at each of the five loci that encode the different components of the T-cell receptor complex in cattle. These genes were mapped on the bovine ge...
Agaba, Morris
,
Kemp, Stephen J.
,
Barendse, W.
,
Teale, A.J.
,
[Genetic mapping of bovine T-cell receptor complex loci]
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Genetic mapping of bovine T-cell receptor complex loci
A two species comparative genome scanning approach has been taken to mapping, and eventually identifying, genes at quantitative trait loci (QTL) influencing resistance to trypanosomosis due to infection with Trypanosoma congolense. Using two large murine F2 and two F6 advanced intercross populati...
Teale, A.J.
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Agaba, Morris
,
Clapcott, S.J.
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Gelhaus, A.
,
Haley, C.
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Psifidis, A.
,
Horstmann, R.
,
Iraqui, F.
,
Kemp, Stephen J.
,
Nilsson, P.
,
Schwerin, M.
,
Sekikawa, K.
,
Soller, M.
,
Sugimoto, Y.
,
Womack, J.
,
[Resistance to trypanosomosis: Of markers, genes and mechanisms]
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Resistance to trypanosomosis: Of markers, genes and mechanisms
Lysosomal alpha-mannosidase is involved in the metabolism of mannoses in oligosaccharides in lysosomes. Deficiency of alpha-mannosidase, alpha-mannosidosis, has been described as an autosomal recessive storage disease in angus cattle, Galloway cattle and in cats. It is caused by non-synonymous su...
Several West African Bos taurus cattle breeds show a remarkable ability to survive and be productive in the face of a trypanosome challenge which would quickly kill susceptible cattle. This phenomenon, termed trypanotolerance, offers a sustainable approach to improving cattle productivity in the...