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A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitaem...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomiasis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomiasis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
Teale, A.J.[Molecular genetic characterisation of animal species, with particular reference to disease resistance and susceptibility]Molecular genetic characterisation of animal species, with particular reference to disease resistance and susceptibility

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localisation of genes controlling resistance to trypanosomiasis in mice]Localisation of genes controlling resistance to trypanosomiasis in mice

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...


Kemp, Stephen J.Teale, A.J.[Genetic basis of trypanotolerance in cattle and mice]Genetic basis of trypanotolerance in cattle and mice

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice

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