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The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin) and Tnfb (lymphotoxin-alpha) (Semon et al 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC) region. Tnfa and soluble lymphotoxin al...


Iraqi, F.A.Teale, A.J.[Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains]Polymorphism in the microsatellite located in the promoters of the Tnfa and Tnfb genes of different mouse strains

In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. Twelve inbre...


Iraqi, F.A.Teale, A.J.[Polymorphisms, in the Tnfa gene of different inbred mouse strains]Polymorphisms, in the Tnfa gene of different inbred mouse strains

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...


Kemp, Stephen J.Teale, A.J.[Genetic basis of trypanotolerance in cattle and mice]Genetic basis of trypanotolerance in cattle and mice

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice

Quantitative trait loci (QTL) associated with resistance to an intestinal worm in a well-defined murine model are described. These have been identified in an F(2) population derived from resistant (SWR) and susceptible (CBA) parental mouse strains infected with the gastro-intestinal nematode par...


Iraqi, F.A.Behnke, J.M.Menge, D.M.Lowe, A.M.Teale, A.J.Gibson, John P.Baker, L.R.Wakelin, D.R.[Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice]Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice
Toye, Philip G.MacHugh, Niall D.Bensaid, A.M.Alberti, S.Teale, A.J.Morrison, W. Ivan[Transfection into mouse L cells of two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygoud animal: Evidence for a second class I locus in cattle]Transfection into mouse L cells of two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygoud animal: Evidence for a second class I locus in cattle

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin)and Tnfb (lymphotoxin-alpha) (Semon et al. 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC)region. Tnfa and soluble lymphotoxin alp...


Iraqi, F.A.Teale, A.J.[Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice]Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice

Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...


Menge, D.M.Behnke, J.M.Iraqi, F.A.Lowe, A.Teale, A.J.Gibson, John P.Wakelin, D.Baker, R.L.[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice

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