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Human chromosome (Chr) 18(HSA 18) contains approximately 85 million base pains of DNA. Thirty genes and pseudogenes have been mapped to HSA 18 by somatic cell genetics or in situ hybridization. Two bovine genes - Yamaguchi sacroma viral oncogene homology 1 (YESI) and desmocollin type 1 (DSC1) - h...


Agaba, MorrisKemp, Stephen J.Barendse, W.Teale, A.J.[Comparative mapping in cattle of genes located on human chromosome 18]Comparative mapping in cattle of genes located on human chromosome 18

A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
Naessens, JanNewson, J.Bensaid, A.Teale, A.J.Magondu, J.Black, S.J.[De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle]De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
Kemp, Stephen J.Maillard, J.C.Teale, A.J.[A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification]A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification
Bensaid, A.M.Kaushal, A.MacHugh, Niall D.Shapiro, S.Z.Teale, A.J.[Biochemical characterization of activation associated bovine class I major histocompatibility complex antigens]Biochemical characterization of activation associated bovine class I major histocompatibility complex antigens

Two bovine bacterial artificial chromosome clones were screened by PCR to amplify the tumour necrosis factor alpha (TNFA) gene. DNA extraction and Southern blotting and probing with a (GT)10 oligonucleotide were performed, followed by cloning into the pUC19 vector. A 0.9 kb fragment containing se...


Wambugu, J.Kanguha, E.Hanotte, Olivier H.Davis, S.Taylor, J.Skow, L.Brunner, R.Schwerin, M.Teale, A.J.Iraqi, F.A.[Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone]Identification of two polymorphic microsatellite repeats on a bovine TNFA-containing BAC clone
Bensaid, A.M.Kaushal, A.Young, J.R.Teale, A.J.[Organisation genomique du Complex majeur d'histocompatibilite du bovin]Organisation genomique du Complex majeur d'histocompatibilite du bovin

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