West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...
Naessens, Jan
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Leak, S.G.A.
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Kennedy, D.J.
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Kemp, Stephen J.
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Teale, A.J.
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[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]
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Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
We have previously reported the results of genome-wide searches in two murine F2 populations for QTLs that influence survival following Trypanosoma congolense infection. Three loci, Tir1, Tir2, and Tir3, were identified and mapped to mouse Chromosomes (Chrs) 17, 5, and 1 respectively, with confid...
Iraqi, F.A.
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Clapcott, S.J.
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Kumari, P.
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Haley, C.S.
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Kemp, Stephen J.
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Teale, A.J.
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[Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines]
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Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines
Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...
The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...
Some West African Bos taurus cattle breeds such as the N'Dama and a number of West African Shorthorns are resistant to tsetse fly-transmitted trypanosomosis. The trait is termed trypanotolerance, for which changes in packed red cell volume percent (PCV) and growth rate following infection are ge...
Waaij, E.H. van der
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Hanotte, Olivier H.
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Arendonk, Johan A.M. van
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Kemp, Stephen J.
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Kennedy, D.
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Gibson, John P.
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Teale, A.J.
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[Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle]
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Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle