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A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle

Summarises the impact of trypanosomiasis on development of trypanotolerant livestock. Describes current genetic research being carried out by collaborating national and international organisations in the African Trypanotolerant Livestock Network, and discusses the importance of conserving these g...


Trail, J.C.M.D'Ieteren, G.D.M.Teale, A.J.[Trypanotolerance and the value of conserving livestock genetic resources]Trypanotolerance and the value of conserving livestock genetic resources

To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chrom...


Kemp, Stephen J.Darvasi, A.Soller, M.Teale, A.J.[Genetic control of resistance to trypanosomiasis]Genetic control of resistance to trypanosomiasis

Inbred strains of laboratory mice exhibit marked differences in survival time following infection with Trypanosoma congolense, the principal cause of trypanosomiasis in African livestock.The difference in survival time between the relatively resistant C57BL/6 J and more susceptible BALB/c inbred ...


Clapcott, S.J.Teale, A.J.Kemp, Stephen J.[Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice]Evidence for genomic imprinting of the major QTL controlling susceptibility to trypanosomiasis in mice

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differenc...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the severe anaemia and production loss...


Kemp, Stephen J.Teale, A.J.[The genetic basis of trypanotolerance in mice and cattle]The genetic basis of trypanotolerance in mice and cattle

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localisation of genes controlling resistance to trypanosomiasis in mice]Localisation of genes controlling resistance to trypanosomiasis in mice

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