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Four single-strand conformation variants of the bovine tumor necrosis factor alpha gene by analysis of PCR-amplified fragments were identified. The variants are inherited in Mendelian fashion and are informative for linkage mapping. We have mapped the bovine gene to Chromosome (Chr) 23 in a panel...


Agaba, MorrisKemp, Stephen J.Barendse, W.Teale, A.J.[Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23]Polymorphism at the bovine tumor necrosis factor alpha locus and assignment to BTA 23

Human chromosome (Chr) 18(HSA 18) contains approximately 85 million base pains of DNA. Thirty genes and pseudogenes have been mapped to HSA 18 by somatic cell genetics or in situ hybridization. Two bovine genes - Yamaguchi sacroma viral oncogene homology 1 (YESI) and desmocollin type 1 (DSC1) - h...


Agaba, MorrisKemp, Stephen J.Barendse, W.Teale, A.J.[Comparative mapping in cattle of genes located on human chromosome 18]Comparative mapping in cattle of genes located on human chromosome 18

A preliminary search for QTLs in a cattle F2 resource populations segregating for trypanotolerance has revealed three large candidate chromosomal regions (Bta02, Bta05, Bta07). In order to narrow down the position of the trypanotolerant QTLs, we are building comparative chromosomal maps between c...


Nilsson, P.H.Kang'a, S.Rottengatter, K.Suedbeck, U.Iraqui, F.Mwakaya, J.Mwangi, D.Womack, J.E.Goldammer, T.Schwerin, M.Bradley, D.Agaba, MorrisSugimoto, K.Gelhaus, A.Horstmann, R.Teale, A.J.Kemp, Stephen J.Hanotte, Olivier H.[Radiation hybrid maps of candidate trypanotolerance regions in cattle]Radiation hybrid maps of candidate trypanotolerance regions in cattle

We have sought to test the possibility of detecting regions of the genome under selection through effects on variation at linked neutral genetic markers. Particularly, we investigated three genomic regions identified by mapping in a cross-bred pedigree as harbouring QTL for trypanosomiasis tolera...


Park, S.D.E.Adomefa, K.Dao, B.Hanotte, Olivier H.Kemp, Stephen J.Sow, R.S.Teale, A.J.Bradley, D.G.[Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance]Application of population genetic analysis of linked, mapped microsatellites to the identification of loci under selection for disease resistance
Iraqui, F.Marteen, S.Teale, A.J.[TNF-alpha expression in trypanosomiasis resistant and susceptible mouse strains during infection with Trypanosoma congolense]TNF-alpha expression in trypanosomiasis resistant and susceptible mouse strains during infection with Trypanosoma congolense

West African N'Dama cattle have developed a genetic capacity to survive, reproduce and remain productive under trypanosomosis risk. The cellular and molecular bases of this so-called trypanotolerance are not known, but the trait is manifested by the N'Dama's greater capacity to control parasitae...


Naessens, JanLeak, S.G.A.Kennedy, D.J.Kemp, Stephen J.Teale, A.J.[Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense]Responses of bovine chimaeras combining trypanosomosis resistant and susceptible genotypes to experimental infection with Trypanosoma congolense
Naessens, JanNewson, J.Bensaid, A.Teale, A.J.Magondu, J.Black, S.J.[De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle]De novo expression of T-cell markers on Theileria parva-transformed lymphoblasts in cattle

Natural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differen...


Naessens, JanTeale, A.J.Sileghem, M.R.[Identification of mechanisms of natural resistance to African trypanosomiasis in cattle]Identification of mechanisms of natural resistance to African trypanosomiasis in cattle
Kemp, Stephen J.Maillard, J.C.Teale, A.J.[A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification]A polymorphism in the bovine gamma-S-crystallin gene revealed by allele-specific amplification
Bensaid, A.M.Kaushal, A.MacHugh, Niall D.Shapiro, S.Z.Teale, A.J.[Biochemical characterization of activation associated bovine class I major histocompatibility complex antigens]Biochemical characterization of activation associated bovine class I major histocompatibility complex antigens

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