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Sitta, TatjanaHenson, Sonal P.Morrison, W. IvanToye, Philip G.[Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo]Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo

Kivali, V.Thomas, L.Toye, Philip G.Fèvre, Eric M.[Diagnosis of porcine cysticercosis using lateral flow assay and HP10 Ag ELISA]Diagnosis of porcine cysticercosis using lateral flow assay and HP10 Ag ELISA

The major histocompatibility complex (MHC) region contains many genes that are key regulators of both innate and adaptive immunity including the polymorphic MHCI and MHCII genes. Consequently, the characterisation of the repertoire of MHC genes is critical to understanding the variation that dete...


Vasoya, D.Law, A.Motta, P.Mingyan YuMuwonge, A.Cook, Elizabeth A.J.Xiaoying LiBryson, K.MacCallam, A.Sitt, T.Toye, Philip G.Bronsvoort, B.M. de C.Watson, MickMorrison, W. IvanConnelley, T.[Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing]Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing

Smallholder dairy farming is seen as a viable and promising activity to support the livelihoods of cattle keepers in low-income countries. This farming system, characterized by small herds of improved cattle raised under zero-grazing, is proven to lead to better milk yields, but also to require m...


Alonso, SilviaToye, Philip G.Msalya, G.Grace, DeliaUnger, Fred[Smallholder dairy farming in Tanzania: Farming practices, animal health and public health challenges and opportunities]Smallholder dairy farming in Tanzania: Farming practices, animal health and public health challenges and opportunities

Alonso, SilviaMsalya, G.Toye, Philip G.Grace, DeliaUnger, Fred[Ancient farming styles and old zoonoses: Brucellosis and Q fever among pastoralist and smallholder cattle herds in Tanzania]Ancient farming styles and old zoonoses: Brucellosis and Q fever among pastoralist and smallholder cattle herds in Tanzania

Cook, Elizabeth A.J.Thomas, L.Glanville, William A. deBronsvoort, B.M. de C.Toye, Philip G.Agwanda, B.Wamae, N.Kariuki, S.Fèvre, Eric M.[International partnerships - Shining light on the neglected zoonoses]International partnerships - Shining light on the neglected zoonoses

Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions ...


Hemmink, J.D.Weir, W.MacHugh, Niall D.Graham, S.P.Patel, EktaPaxton, E.Shiels, B.Toye, Philip G.Morrison, W. IvanPelle, Roger[Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva]Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva

Background The tick-borne protozoan parasite Theileria parva causes a usually fatal cattle disease known as East Coast fever in sub-Saharan Africa, with devastating consequences for poor small-holder farmers. Immunity to T. parva, believed to be mediated by a cytotoxic T lymphocyte (CTL) response...


Steinaa, LucillaSvitek, NichiolasAwino, EliasNjoroge, ThomasSaya, Rosemary M.Toye, Philip G.[Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals]Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals

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