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capacity and infrastructure of government services for disease identification and control are often limited. In the absence of systematic surveillance systems for animal diseases, the information on pathogens affecting livestock has been filled by targeted surveys conducted in certain locations a...


Alonso, SilviaToye, Philip G.Jores, JoergWakhungu, Judi W.Msalya, G.Grace, DeliaUnger, Fred[The known and the unknowns: A multipathogen survey to identify diseases in cattle herds in Tanzania]The known and the unknowns: A multipathogen survey to identify diseases in cattle herds in Tanzania

Cattle diseases remain a major constraint to increasing dairy productivity in Tanzania, by killing or keeping them sick and under-producing. Recent studies report overall mortality between 12 and 14 % in smallholder dairy cattle across different regions of Tanzania. Many of these diseases can als...


Alonso, SilviaUnger, FredToye, Philip G.Jores, JoergWakhungu, Judi W.Msalya, G.Grace, Delia[Cattle diseases in dairy herds in Tanzania: Farmers’ view and laboratory confirmation]Cattle diseases in dairy herds in Tanzania: Farmers’ view and laboratory confirmation

Peste des petits ruminants virus (PPRV) causes an economically important disease of sheep and goats, primarily in developing countries. It is becoming the object of intensive international control efforts. Current vaccines do not allow vaccinated and infected animals to be distinguished (no DIVA ...


Holzer, B.Taylor, G.Rajko-Nenow, P.Hodgson, S.Okoth, Edward A.Herbert, R.Toye, Philip G.Baron, M.D.[Determination of the minimum fully protective dose of adenovirus-based DIVA vaccine against peste des petits ruminants virus challenge in East African goats]Determination of the minimum fully protective dose of adenovirus-based DIVA vaccine against peste des petits ruminants virus challenge in East African goats

Tick-borne diseases are a major impediment to improved productivity of livestock in sub-Saharan Africa. Improved control of these diseases would be assisted by detailed epidemiological data. Here we used longitudinal, serological data to determine the patterns of exposure to Theileria parva, Thei...


Kiara, Henry K.Jennings, A.Bronsvoort, B.M. de C.Hande, I.G.Mwangi, S.T.Mbole-Kariuki, Mary N.Wyk, I.C. vanPoole, Elizabeth J.Hanotte, Olivier H.Coetzer, J.A.W.Woolhouse, Mark E.J.Toye, Philip G.[A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya]A longitudinal assessment of the serological response to Theileria parva and other tick-borne parasites from birth to one year in a cohort of indigenous calves in western Kenya

Parasite burden varies widely between individuals within a population, and can covary with multiple aspects of individual phenotype. Here we investigate the sources of variation in faecal strongyle eggs counts, and its association with body weight and a suite of haematological measures, in a coho...


Callaby, R.Hanotte, Olivier H.Wyk, I.C. vanKiara, Henry K.Toye, Philip G.Mbole-Kariuki, Mary N.Jennings, A.Thumbi, S.M.Coetzer, J.A.W.Bronsvoort, B.M. de C.Knott, S.A.Woolhouse, Mark E.J.Kruuk, L.E.B.[Variation and covariation in strongyle infection in East African shorthorn zebu calves]Variation and covariation in strongyle infection in East African shorthorn zebu calves
Toye, Philip G.Teale, A.J.[Gene transfection in mammalian cells and its application in studies of immunity to East Coast fever]Gene transfection in mammalian cells and its application in studies of immunity to East Coast fever

Initial comparison of 2 polymorphic, immunodominant molecule (PIM) cDNA sequences from Theileria parva suggested that the PIM genes consist of conserved 5' and 3' termini flanking a central variable region. Further evidence is presented, based on sequence analysis, supporting this general structu...


Toye, Philip G.Gobright, E.I.Nyanjui, J.Nene, VishvanathBishop, Richard P.[Structure and sequence variation of the genes encoding the polymorphic, immunodominant molecule (PlM), a candidate diagnostic antigen of Theileria parva]Structure and sequence variation of the genes encoding the polymorphic, immunodominant molecule (PlM), a candidate diagnostic antigen of Theileria parva
Toye, Philip G.Goddeeris, M.Iams, K.P.Musoke, A.J.Morrison, W. Ivan[Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva]Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva

Most studies of infectious diseases in East African cattle have concentrated on gastro-intestinal parasites and vector-borne diseases. As a result, relatively little is known about viral diseases, except for those that are clinically symptomatic or which affect international trade such as foot an...


Callaby, R.Toye, Philip G.Jennings, A.Thumbi, S.M.Wyk, I.C. vanHanotte, Olivier H.Mbole-Kariuki, Mary N.Bronsvoort, B.M. de C.Kruuk, L.E.B.Woolhouse, Mark E.J.Kiara, Henry K.[Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya]Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya

Grace, DeliaToye, Philip G.Tarawali, Shirley A.Nene, Vishvanath[Vaccines and diagnostics—The case for regional One Health centres of excellence]Vaccines and diagnostics—The case for regional One Health centres of excellence

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