Most studies of infectious diseases in East African cattle have concentrated on gastro-intestinal parasites and vector-borne diseases. As a result, relatively little is known about viral diseases, except for those that are clinically symptomatic or which affect international trade such as foot an...
Callaby, R.
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Toye, Philip G.
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Jennings, A.
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Thumbi, S.M.
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Wyk, I.C. van
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Hanotte, Olivier H.
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Mbole-Kariuki, Mary N.
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Bronsvoort, B.M. de C.
,
Kruuk, L.E.B.
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Woolhouse, Mark E.J.
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Kiara, Henry K.
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[Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya]
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Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya
Field and experimental bovine infection sera were used in immunoblots of sporozoite and schizont lysates of Theileria parva to identify candidate diagnostic antigens. Four parasite antigens of Mr 67,000 (p67), 85,000 (the polymorphic immunodominant molecule, PIM), 104,000 (p104), and 150,000 (p15...
Katende, J.
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Morzaria, S.P.
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Toye, Philip G.
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Skilton, Robert A.
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Nene, Vishvanath
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Nkonge, C.
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Musoke, A.J.
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[An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule]
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An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule
Goddeeris, B.M.
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Toye, Philip G.
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Morrison, W. Ivan
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[Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC]
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Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC
Toye, Philip G.
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MacHugh, Niall D.
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Bensaid, A.M.
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Alberti, S.
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Teale, A.J.
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Morrison, W. Ivan
,
[Transfection into mouse L cells of two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygoud animal: Evidence for a second class I locus in cattle]
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Transfection into mouse L cells of two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygoud animal: Evidence for a second class I locus in cattle
The Kenyan East African zebu cattle are valuable and widely used genetic resources. Previous studies using microsatellite loci revealed the complex history of these populations with the presence of taurine and zebu genetic backgrounds. Here, we estimate at genome-wide level the genetic compositio...
Mbole-Kariuki, Mary N.
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Sonstegard, T.S.
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Orth, Alan
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Thumbi, S.M.
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Bronsvoort, B.M. de C.
,
Kiara, Henry K.
,
Toye, Philip G.
,
Conradie, I.
,
Jennings, A.
,
Coetzer, K.
,
Woolhouse, Mark E.J.
,
Hanotte, Olivier H.
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Tapio, M.
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[Genome-wide analysis reveals the ancient and recent admixture history of East African Shorthorn Zebu from Western Kenya]
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Genome-wide analysis reveals the ancient and recent admixture history of East African Shorthorn Zebu from Western Kenya
In natural populations, individuals may be infected with multiple distinct pathogens at a time. These pathogens may act independently or interact with each other and the host through various mechanisms, with resultant varying outcomes on host health and survival. To study effects of pathogens and...
Thumbi, S.M.
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Bronsvoort, B.M. de C.
,
Poole, Elizabeth J.
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Kiara, Henry K.
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Toye, Philip G.
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Mbole-Kariuki, Mary N.
,
Conradie, I.
,
Jennings, A.
,
Handel, I.G.
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Coetzer, J.A.W.
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Steyl, J.C.A.
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Hanotte, Olivier H.
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Woolhouse, Mark E.J.
,
[Parasite co-infections and their impact on survival of indigenous cattle]
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Parasite co-infections and their impact on survival of indigenous cattle
The presence of bluetongue virus (BTV) and Epizootic Haemorrhagic Disease virus (EHDV) in indigenous calves in western Kenya was investigated. Serum was analysed for BTV and EHDV antibodies. The population seroprevalences for BTV and EHDV for calves at 51 weeks of age were estimated to be 0.942 (...
Toye, Philip G.
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Batten, C.A.
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Kiara, Henry K.
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Henstock, M.R.
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Edwards, L.
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Thumbi, S.M.
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Poole, Elizabeth J.
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Handel, I.G.
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Bronsvoort, B.M. de C.
,
Hanotte, Olivier H.
,
Coetzer, J.A.W.
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Woolhouse, Mark E.J.
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Oura, C.A.L.
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[Bluetongue and epizootic haemorrhagic disease virus in local breeds of cattle in Kenya]
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Bluetongue and epizootic haemorrhagic disease virus in local breeds of cattle in Kenya
The passive transfer of antibodies from dams to offspring via colostrum is believed to play an important role in protecting neonatal mammals from infectious disease. The study presented here investigates the uptake of colostrum by 548 calves in western Kenya maintained under smallholder farming, ...
Toye, Philip G.
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Handel, I.
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Gray, J.
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Kiara, Henry K.
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Thumbi, S.M.
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Jennings, A.
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Wyk, I.C. van
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Ndila, M.
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Hanotte, Olivier H.
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Coetzer, K.
,
Woolhouse, Mark E.J.
,
Bronsvoort, B.M. de C.
,
[Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya]
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Maternal antibody uptake, duration and influence on survival and growth rate in a cohort of indigenous calves in a smallholder farming system in western Kenya
The accurate estimation of livestock weights is important for many aspects of livestock management including nutrition, production and appropriate dosing of pharmaceuticals. Subtherapeutic dosing has been shown to accelerate pathogen resistance which can have subsequent widespread impacts. There ...
Lesosky, M.
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Dumas, S.
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Conradie, I.
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Handel, I.G.
,
Jennings, A.
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Thumbi, S.M.
,
Toye, Philip G.
,
Bronsvoort, B.M. de C.
,
[A live weight-heart girth relationship for accurate dosing of east African shorthorn zebu cattle]
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A live weight-heart girth relationship for accurate dosing of east African shorthorn zebu cattle
The protozoan parasite Theileria parva causes a usually fatal disease in cattle, known as East Coast fever. Cattle can be vaccinated by injecting live parasites simultaneously with long acting oxytetracycline (the Infection and Treatment Method, ITM). The immunity induced by ITM is believed to be...
Steinaa, Lucilla
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Saya, R.
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Awino, Elias
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Toye, Philip G.
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[Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen]
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Cytotoxic T lymphocytes from cattle immunized against Theileria parva exhibit pronounced cross-reactivity among different strain-specific epitopes of the Tp1 antigen