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Background The tick-borne protozoan parasite Theileria parva causes a usually fatal cattle disease known as East Coast fever in sub-Saharan Africa, with devastating consequences for poor small-holder farmers. Immunity to T. parva, believed to be mediated by a cytotoxic T lymphocyte (CTL) response...


Steinaa, LucillaSvitek, NichiolasAwino, EliasNjoroge, ThomasSaya, Rosemary M.Toye, Philip G.[Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals]Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals

T cell responses contribute to immunity against many intracellular infections. There is, for example, strong evidence that major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs) play an essential role in mediating immunity to East Coast fever (ECF), a fatal lymph...


Nene, VishvanathSvitek, NicholasToye, Philip G.Golde, W.T.Barlow, J.Buus, SorenNielsen, Morten[Designing bovine T cell vaccines via reverse immunology]Designing bovine T cell vaccines via reverse immunology

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