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Sitta, TatjanaHenson, Sonal P.Morrison, W. IvanToye, Philip G.[Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo]Similar levels of diversity in the gene encoding the p67 sporozoite surface protein of Theileria parva are observed in blood samples from buffalo and cattle naturally infected from buffalo

The major histocompatibility complex (MHC) region contains many genes that are key regulators of both innate and adaptive immunity including the polymorphic MHCI and MHCII genes. Consequently, the characterisation of the repertoire of MHC genes is critical to understanding the variation that dete...


Vasoya, D.Law, A.Motta, P.Mingyan YuMuwonge, A.Cook, Elizabeth A.J.Xiaoying LiBryson, K.MacCallam, A.Sitt, T.Toye, Philip G.Bronsvoort, B.M. de C.Watson, MickMorrison, W. IvanConnelley, T.[Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing]Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing

Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity
Naessens, JanSileghem, M.R.MacHugh, Niall D.Park, Y.H.Davis, W.C.Toye, Philip G.[Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene]Selection of BoCD25 monoclonal antibodies by screening mouse L cells transfected with the bovine p55-interleukin-2 (IL-2) receptor gene

African Cape buffalo (Syncerus caffer) is the wildlife reservoir of multiple species within the apicomplexan protozoan genus Theileria, including Theileria parva which causes East coast fever in cattle. A parasite, which has not yet been formally named, known as Theileria sp. (buffalo) has been r...


Bishop, Richard P.Hemmink, W.I.Morrison, J.D.Weir, W.Toye, Philip G.Sitt, T.Spooner, P.R.Musoke, A.J.Skilton, Robert A.Odongo, David O.[The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes]The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes
Toye, Philip G.Goddeeris, M.Iams, K.P.Musoke, A.J.Morrison, W. Ivan[Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva]Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva

Most studies of infectious diseases in East African cattle have concentrated on gastro-intestinal parasites and vector-borne diseases. As a result, relatively little is known about viral diseases, except for those that are clinically symptomatic or which affect international trade such as foot an...


Callaby, R.Toye, Philip G.Jennings, A.Thumbi, S.M.Wyk, I.C. vanHanotte, Olivier H.Mbole-Kariuki, Mary N.Bronsvoort, B.M. de C.Kruuk, L.E.B.Woolhouse, Mark E.J.Kiara, Henry K.[Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya]Seroprevalence of respiratory viral pathogens of indigenous calves in western Kenya

Field and experimental bovine infection sera were used in immunoblots of sporozoite and schizont lysates of Theileria parva to identify candidate diagnostic antigens. Four parasite antigens of Mr 67,000 (p67), 85,000 (the polymorphic immunodominant molecule, PIM), 104,000 (p104), and 150,000 (p15...


Katende, J.Morzaria, S.P.Toye, Philip G.Skilton, Robert A.Nene, VishvanathNkonge, C.Musoke, A.J.[An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule]An enzyme-linked immunosorbent assay for detection of Theileria parva antibodies in cattle using a recombinant polymorphic immunodominant molecule
Goddeeris, B.M.Toye, Philip G.Morrison, W. Ivan[Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC]Strain specificity of bovine Theileria parva-specific cytotoxic T cells is determined by the phenotype of the restricting class I MHC
Toye, Philip G.MacHugh, Niall D.Bensaid, A.M.Alberti, S.Teale, A.J.Morrison, W. Ivan[Transfection into mouse L cells of two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygoud animal: Evidence for a second class I locus in cattle]Transfection into mouse L cells of two serologically and functionally distinct bovine class I MHC molecules from a MHC-homozygoud animal: Evidence for a second class I locus in cattle

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