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Journal Article 2018-05-02

Autor: Steinaa, Lucilla Svitek, Nichiolas Awino, Elias Njoroge, Thomas Saya, Rosemary M. Toye, Philip G.

Background The tick-borne protozoan parasite Theileria parva causes a usually fatal cattle disease known as East Coast fever in sub-Saharan Africa, with devastating consequences for poor small-holder farmers. Immunity to T. parva, believed to be mediated by a cytotoxic T lymphocyte (CTL) response...

Enlace original: https://cgspace.cgiar.org/handle/10568/96893

Investigación en Agricultura
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Steinaa, Lucilla ,  Svitek, Nichiolas ,  Awino, Elias ,  Njoroge, Thomas ,  Saya, Rosemary M. ,  Toye, Philip G. ,  [Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals] ,  Immunization with one Theileria parva strain results in similar level of CTL strain-specificity and protection compared to immunization with the three-component Muguga cocktail in MHC-matched animals
Journal Article 2018-01-17

Autor: Steinaa, Lucilla Svitek, Nicholas Awino, Elias Saya, Rosemary Toye, Philip G.

Objectives: The objective of this study was to assess whether cytotoxic T cells (CTL) generated by the live vaccine, known as “ITM Muguga cocktail”, which is used for the cattle disease East Cost fever (ECF) in Sub-Saharan Africa, showed a broad reactivity against many different strains of the ca...

Enlace original: https://cgspace.cgiar.org/handle/10568/92437

Investigación en Agricultura
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Steinaa, Lucilla ,  Svitek, Nicholas ,  Awino, Elias ,  Saya, Rosemary ,  Toye, Philip G. ,  [Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity] ,  Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity
Journal Article 2017-06-27

Autor: Mariner, Jeffrey C. Gachanja, J. Tindih, H.S. Toye, Philip G.

The research objective was to develop a thermostable vaccine against peste des petits ruminants (PPR), a morbilliviral disease of small ruminants targeted for eradication that is a major constraint on the livelihoods of the rural poor throughout much of Africa and Asia. Although existing PPR vacc...

Enlace original: https://cgspace.cgiar.org/handle/10568/81517

Investigación en Agricultura
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Mariner, Jeffrey C. ,  Gachanja, J. ,  Tindih, H.S. ,  Toye, Philip G. ,  [A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia] ,  A thermostable presentation of the live, attenuated peste des petits ruminants vaccine in use in Africa and Asia
Journal Article 1991

Autor: Toye, Philip G. Goddeeris, M. Iams, K.P. Musoke, A.J. Morrison, W. Ivan
Enlace original: https://cgspace.cgiar.org/handle/10568/29374

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Toye, Philip G. ,  Goddeeris, M. ,  Iams, K.P. ,  Musoke, A.J. ,  Morrison, W. Ivan ,  [Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva] ,  Characterization of a polymorphic immunodominant molecule in sporozoites and schizonts of Theileria parva
Journal Article 1995

Autor: Toye, Philip G. Metzelaar, M.J. Wijngaard, P.L.J. Nene, Vishvanath Iams, K.P. Roose, J. Nyanjui, J.K. Gobright, E.I. Musoke, A.J. Clevers, H.C.

Theileria parva, a tick-transmitted protozoan parasite related to Plasmodium spp., causes the disease East Coast fever, an acute and usually fatal lymphoproliferative disorder of cattle in Africa. Previous studies using sera from cattle that have survived infection identified a polymorphic immuno...

Enlace original: https://cgspace.cgiar.org/handle/10568/28923

Investigación en Agricultura
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Toye, Philip G. ,  Metzelaar, M.J. ,  Wijngaard, P.L.J. ,  Nene, Vishvanath ,  Iams, K.P. ,  Roose, J. ,  Nyanjui, J.K. ,  Gobright, E.I. ,  Musoke, A.J. ,  Clevers, H.C. ,  [Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva] ,  Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva
Journal Article 2011-06-30

Autor: Patel, Ekta Lubembe, D.M. Gachanja, J. Mwaura, S. Spooner, P.R. Toye, Philip G.

The current Infection and Treatment Method of vaccination against East Coast fever comprises an inoculation of live Theileria parva sporozoites and simultaneous administration of oxytetracycline. Immunization with a combination of parasite types has been shown to provide broader protection than i...

Enlace original: https://cgspace.cgiar.org/handle/10568/3166

Investigación en Agricultura
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Patel, Ekta ,  Lubembe, D.M. ,  Gachanja, J. ,  Mwaura, S. ,  Spooner, P.R. ,  Toye, Philip G. ,  [Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity] ,  Molecular characterization of live Theileria parva sporozoite vaccine stabilates reveals extensive genotypic diversity
Journal Article 2015-08-01

Autor: Sitt, T. Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, S. Njoroge, T. Omondi, G.P. Mutinda, M. Mathenge, J. Prettejohn, G. Morrison, W. Ivan Toye, Philip G.

Integrative management of wildlife and livestock requires a clear understanding of the diseases transmitted between the two populations. The tick-borne protozoan parasite Theileria parva causes two distinct diseases in cattle, East Coast fever and Corridor disease, following infection with parasi...

Enlace original: https://cgspace.cgiar.org/handle/10568/66148

Investigación en Agricultura
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Sitt, T. ,  Poole, Elizabeth J. ,  Ndambuki, Gideon M. ,  Mwaura, S. ,  Njoroge, T. ,  Omondi, G.P. ,  Mutinda, M. ,  Mathenge, J. ,  Prettejohn, G. ,  Morrison, W. Ivan ,  Toye, Philip G. ,  [Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva] ,  Exposure of vaccinated and naive cattle to natural challenge from buffalo-derived Theileria parva
Journal Article 2018-09-15

Autor: Sitt, T. Pelle, Roger Chepkwony, M.C. Morrison, W. Ivan Toye, Philip G.
Enlace original: https://cgspace.cgiar.org/handle/10568/98857

Investigación en Agricultura
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Sitt, T. ,  Pelle, Roger ,  Chepkwony, M.C. ,  Morrison, W. Ivan ,  Toye, Philip G. ,  [Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines] ,  Theileria parva antigens recognized by CD8+ T cells show varying degrees of diversity in buffalo-derived infected cell lines
Journal Article 2019-01-31

Autor: Patel, Ekta Mwaura, Stephen Giulio, Giuseppe di Cook, Elizabeth A.J. Lynen, Godelieve Toye, Philip G.
Enlace original: https://cgspace.cgiar.org/handle/10568/99527

Investigación en Agricultura
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Patel, Ekta ,  Mwaura, Stephen ,  Giulio, Giuseppe di ,  Cook, Elizabeth A.J. ,  Lynen, Godelieve ,  Toye, Philip G. ,  [Infection and treatment method (ITM) vaccine against East Coast fever: Reducing the number of doses per straw for use in smallholder dairy herds by thawing, diluting and refreezing already packaged vaccine] ,  Infection and treatment method (ITM) vaccine against East Coast fever: Reducing the number of doses per straw for use in smallholder dairy herds by thawing, diluting and refreezing already packaged vaccine

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