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Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development ...


Graham, S.P.Honda, Y.Pelle, RogerMwangi, D.M.Glew, E.J.Villiers, Etienne P. deShah, TushaarBishop, Richard P.Bruggen, P. van derNene, VishvanathTaracha, E.L.N.[A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology]A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology

We describe the generation of an auto-annotated index of genes that are expressed in the salivary glands of four-day fed female adult Rhipicephalus appendiculatus ticks. A total of 9162 EST sequences were derived from an uninfected tick cDNA library and 9844 ESTs were from a cDNA library from t...


Nene, VishvanathLee, D.Kang'a, S.Skilton, Robert A.Shah, TushaarVilliers, Etienne P. deMwaura, S.Taylor, D.Quackenbush, J.Bishop, Richard P.[Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected with Theileria parva]Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected with Theileria parva

Rab genes encode a subgroup of small GTP-binding proteins within the ras super-family that regulate targeting and fusion of transport vesicles within the secretory and endocytic pathways. These genes are of particular interest in the protozoan phylum Apicomplexa, since a family of Rab GTPases has...


Langsley, G.Noort, V. vanCarret, C.Meissner, M.Villiers, Etienne P. deBishop, Richard P.Pain, A.[Comparative genomics of the Rab protein family in Apicomplexan parasites]Comparative genomics of the Rab protein family in Apicomplexan parasites

Immunity against the bovine intracellular protozoan parasite Theileria parva has been shown to be mediated through the destruction of parasite infected lymphocytes by MHC class I restricted CD8+ CTL. Six parasite proteins targeted by CTL from T. parva immune cattle have been identified and raised...


Graham, S.P.Pelle, RogerVilliers, Etienne P. deYamage, M.Mwangi, D.M.Honda, Y.Ellis, S.A.MacHugh, Niall D.Morrison, W. IvanTaracha, E.L.N.[Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva]Identification of bovine cytotoxic T lymphocyte epitopes on the intracellular parasite Theileria Parva

Plasmodium belongs to the phylum Apicomplexa. Within the Apicomplexa, Plasmodium, Toxoplasma and Cryptosporidium are parasites of considerable medical importance while Theileria and Eimeria are animal pathogens. P. falciparum is particularly important as it causes malaria, resulting in more than ...


Githui, E.G.Villiers, Etienne P. deMcArthur, A.G.[Plasmodium possesses dynein light chain classes that are unique and conserved across species]Plasmodium possesses dynein light chain classes that are unique and conserved across species
Gardner, M.J.Bishop, Richard P.Shah, TushaarVilliers, Etienne P. deCarlton, J.M.Hall, N.Ren, Q.Paulsen, I.T.Pain, A.Berriman, M.Wilson, R.J.M.Sato, S.Ralph, S.A.Mann, D.J.Xiong, Z.Shallom, S.J.Weidman, J.Jiang, L.Lynn,, J.Weaver, B.Shoaibi, A.Domingo, A.R.Wasawo, D.Crabtree, J.Wortman, J.R.Haas, B.Angiuoli, S.V.Creasy, T.H.Lu, C.Suh, B.Silva, J.C.Utterback, T.R.Feldblyum, T.V.Pertea, M.Allen, J.Nierman, W.C.Taracha, E.L.N.Salzberg, S.L.White, O.R.Fitzhugh, H.A.Morzaria, S.P.Venter, J. CraigFraser, C.M.Nene, Vishvanath[Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes]Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
Pain, A.Renauld, H.Berriman, M.Murphy, L.Yeats, C.A.Weir, W.Kerhornou, A.Aslett, M.Bishop, Richard P.Bouchier, C.Bouchier, C.Cochet, M.Coulson, R.M.R.Cronin, A.Villiers, Etienne P. deFraser, A.Fosker, N.Gardner, M.Goble, A.Griffiths-Jones, S.Harris, D.E.Katzer, F.Larke, N.Lord, A.Maser, P.McKellar, S.Mooney, P.Morton, F.Nene, VishvanathO'Neil, S.Price, C.Quail, M.A.Rabbinowitsch, E.Rawlings, N.D.Rutter, S.Saunders, D.Seeger, K.Shah, TushaarSquares, R.Squares, S.Tivey, A.Walker, A.R.Woodward, J.Dobbelaere, D.A.E.Langsley, G.Rajandream, M.A.McKeever, Declan J.Shiels, B.Tait, A.Barrell, B.Hall, N.[Genome of the host-cell transforming parasite Theileria annulata compared with T. parva]Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Heartwater, a tick-borne disease of domestic and wild ruminants, is caused by the intracellular rickettsia Ehrlichia ruminantium (previously known as Cowdria ruminantium). It is a major constraint to livestock production throughout subSaharan Africa, and it threatens to invade the Americas, yet t...


Collins, N.E.Liebenberg, J.Villiers, Etienne P. deBrayton, K.A.Louw, E.Pretorius, A.Faber, F.E.Heerden, H. vanJosemans, A.Kleef, M. vanSteyn, H.C.Strijp, M.F. vanZweygarth, E.Jongejan, F.Maillard, J.C.Berthier, D.Botha, M.Joubert, F.Corton, C.H.Thomson, N.R.Allsopp, M.T.Allsopp, B.A.[The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number]The genome of the heartwater agent Ehrlichia ruminantium contains multiple tandem repeats of actively variable copy number
Gichora, N.N.Fatumo, S.A.Ngara, M.V.Chelbat, N.Ramdayal, K.Villiers, Etienne P. deMasiga, Daniel K.Bizzaro, J.W.Suravajhala, P.Ommeh, S.C.Hide, W.[Ten simple rules for organizing a virtual conference—anywhere]Ten simple rules for organizing a virtual conference—anywhere

Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs ...


Lambson, B.Nene, VishvanathObura, M.Shah, TushaarPandit, P.Ole-MoiYoi, O.K.Delroux, K.Welburn, S.C.Skilton, Robert A.Villiers, Etienne P. deBishop, Richard P.[Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells]Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells

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