Background
The neglected zoonotic diseases (NZD) are an understudied group that are a major cause of illness throughout the developing world. In general, little is known about the prevalence and burden of NZDs in affected communities, particularly in relation to other infectious diseases with whi...
Fèvre, Eric M.
,
Glanville, William A. de
,
Thomas, L.F.
,
Cook, Elizabeth A.J.
,
Kariuki, S.
,
Wamae, C.N.
,
[An integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenya]
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An integrated study of human and animal infectious disease in the Lake Victoria crescent small-holder crop-livestock production system, Kenya
Rift Valley fever virus (RVFV) is a zoonotic arbovirus affecting livestock and people. This study was conducted in western Kenya where RVFV outbreaks have not previously been reported. The aims were to document the seroprevalence and risk factors for RVFV antibodies in a community-based sample fr...
Cook, Elizabeth A.J.
,
Grossi-Soyster, E.N.
,
Glanville, William A. de
,
Thomas, L.F.
,
Kariuki, S.
,
Bronsvoort, B.M. de C.
,
Wamae, C.N.
,
LaBeaud, A.D.
,
Fèvre, Eric M.
,
[The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya]
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The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya
Large datasets are often not amenable to analysis using traditional single-step approaches. Here,
our general objective was to apply imputation techniques, principal component analysis (PCA),
elastic net and generalized linear models to a large dataset in a systematic approach to extract
the most...
Tremblay, M.
,
Dahm, J.S.
,
Wamae, C.N.
,
Glanville, William A. de
,
Fèvre, Eric M.
,
Dopfer, D.
,
[Shrinking a large dataset to identify variables associated with increased risk of Plasmodium falciparum infection in Western Kenya]
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Shrinking a large dataset to identify variables associated with increased risk of Plasmodium falciparum infection in Western Kenya
The neglected tropical diseases (NTDs) are characterized by their tendency to cluster within groups of people, typically the poorest and most marginalized. Despite this, measures of clustering, such as within-group correlation or between-group heterogeneity, are rarely reported from community-bas...
Glanville, William A. de
,
Thomas, Lian F.
,
Cook, Elizabeth A.J.
,
Bronsvoort, B.M. de C.
,
Wardrop, N.
,
Wamae, C.N.
,
Kariuki, S.
,
Fèvre, Eric M.
,
[General contextual effects on neglected tropical disease risk in rural Kenya]
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General contextual effects on neglected tropical disease risk in rural Kenya
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional ...
Grossi-Soyster, E.N.
,
Cook, Elizabeth A.J.
,
Glanville, William A. de
,
Thomas, L.F.
,
Krystosik, A.R.
,
Lee, J.
,
Wamae, C.N.
,
Kariuki, S.
,
Fèvre, Eric M.
,
LaBeaud, A.D.
,
[Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya]
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Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya
Taenia spp. infections, particularly cysticercosis, cause considerable health impacts in endemic countries. Despite previous evidence of spatial clustering in cysticercosis and the role of environmental factors (e.g. temperature and humidity) in the survival of eggs, little research has explored ...
Wardrop, N.A.
,
Thomas, L.F.
,
Atkinson, P.M.
,
Glanville, William A. de
,
Cook, Elizabeth A.J.
,
Wamae, C.N.
,
Gabriël, S.
,
Dorny, P.
,
Harrison, L.J.S.
,
Fèvre, Eric M.
,
[The influence of socio-economic, behavioural and environmental factors on Taenia spp. transmission in western Kenya: Evidence from a cross-sectional survey in humans and pigs]
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The influence of socio-economic, behavioural and environmental factors on Taenia spp. transmission in western Kenya: Evidence from a cross-sectional survey in humans and pigs
Evidence suggests that the intracellular bacterial pathogen Coxiella burnetii (which causes Q fever) is widespread, with a near global distribution. While there has been increasing attention to Q fever epidemiology in high-income settings, a recent systematic review highlighted significant gaps i...
Wardrop, N.A.
,
Thomas, L.F.
,
Cook, Elizabeth A.J.
,
Glanville, William A. de
,
Atkinson, P.M.
,
Wamae, C.N.
,
Fèvre, Eric M.
,
[The sero-epidemiology of Coxiella burnetii in humans and cattle, western Kenya: Evidence from a cross-sectional study]
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The sero-epidemiology of Coxiella burnetii in humans and cattle, western Kenya: Evidence from a cross-sectional study
Three hundred forty-three pigs slaughtered and marketed in western Kenya were subjected to lingual examination and HP10 Ag-ELISA for the serological detection of Taenia solium antigen. When estimates were adjusted for the sensitivity and specificity of the diagnostic assays, prevalence of T. soli...
Thomas, L.F.
,
Harrison, L.J.S.
,
Toye, Philip G.
,
Glanville, William A. de
,
Cook, Elizabeth A.J.
,
Wamae, C.N.
,
Fèvre, Eric M.
,
[Prevalence of Taenia solium cysticercosis in pigs entering the food chain in western Kenya]
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Prevalence of Taenia solium cysticercosis in pigs entering the food chain in western Kenya
The tapeworm Taenia solium is the parasite responsible for neurocysticercosis, a neglected tropical disease of public health importance, thought to cause approximately 1/3 of epilepsy cases across endemic regions. The consumption of undercooked infected pork perpetuates the parasite’s life-cycle ...
Thomas, L.F.
,
Glanville, William A. de
,
Cook, Elizabeth A.J.
,
Bronsvoort, B.M. de C.
,
Handel, I.
,
Wamae, C.N.
,
Kariuki, S.
,
Fèvre, Eric M.
,
[Modelling the risk of Taenia solium exposure from pork produced in western Kenya]
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Modelling the risk of Taenia solium exposure from pork produced in western Kenya