Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...
Gorkhali, N.A.
,
Kunzhe Dong
,
Min Yang
,
Shen Song
,
Kader, A.
,
Shrestha, B.S.
,
Xiaohong He
,
Qian-Jun Zhao
,
Yabin Pu
,
Xiangchen Li
,
Kijas, J.
,
Weijun, Guan
,
Han Jianlin
,
Lin Jiang
,
Yuehui Ma
,
[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]
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Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas
MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...
Qian-Jun Zhao
,
Ye Kang
,
Hong-Yang Wang
,
Weijun, Guan
,
Xiang-Chen Li
,
Lin Jiang
,
Xiao-Hong He
,
Yabin Pu
,
Han Jianlin
,
Yue-Hui Ma
,
Qian-Jun Zhao
,
[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]
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Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development
Y chromosome acts as a single nonrecombining unit that is male specific and in effect haploid, thus ensuring the preservation of mutational events as a single haplotype via male lines. In this study, 6 Y chromosome–specific microsatellites (SSR) were tested for the patrilineal genetic variations ...
Yinghui, Ling
,
Yue-Hui Ma
,
Weijun, Guan
,
Yuejiao, Cheng
,
Yanping, Wang
,
Dapeng, J.
,
Lai, M.
,
Halik, M.
,
Han Jianlin
,
[Identification of Y chromosome genetic variations in Chinese indigenous horse breeds]
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Identification of Y chromosome genetic variations in Chinese indigenous horse breeds
In order to investigate the genetic differentiation, we studied the genetic structure and genetic
variation of 23 Chinese indigenous horse breeds and one thoroughbred horse population using 25 microsatellite
markers. The number of alleles, polymorphism information content (PIC) and heterozygosity...
Yinghui, L.
,
Yuejiao, C.
,
Yanping, W.
,
Weijun, Guan
,
Baoling, F.
,
Qian-Jun Zhao
,
Xiaohong, H.
,
Yabin Pu
,
Yue-Hui Ma
,
Han Jianlin
,
[Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers]
,
Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers
Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel b...
Desmoglein 4 (DSG4) plays an important role in the regulation of growth and differentiation of hair follicles in mammals. In this study, a 755 bp long segment of DSG4 was screened in 544 sheep sampled from nine Chinese indigenous breeds and two Western breeds using PCR-SSCP assay with three diffe...
Yue-Hui Ma
,
Ge, Zhang
,
Yuan-yue, Zhang
,
Weijun, Guan
,
Qian-Jun Zhao
,
Hui-jing, Zhao
,
Han Jianlin
,
[Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium]
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Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium