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Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...


Gorkhali, N.A.Kunzhe DongMin YangShen SongKader, A.Shrestha, B.S.Xiaohong HeQian-Jun ZhaoYabin PuXiangchen LiKijas, J.Weijun, GuanHan JianlinLin JiangYuehui Ma[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas

MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...


Qian-Jun ZhaoYe KangHong-Yang WangWeijun, GuanXiang-Chen LiLin JiangXiao-Hong HeYabin PuHan JianlinYue-Hui MaQian-Jun Zhao[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development

Y chromosome acts as a single nonrecombining unit that is male specific and in effect haploid, thus ensuring the preservation of mutational events as a single haplotype via male lines. In this study, 6 Y chromosome–specific microsatellites (SSR) were tested for the patrilineal genetic variations ...


Yinghui, LingYue-Hui MaWeijun, GuanYuejiao, ChengYanping, WangDapeng, J.Lai, M.Halik, M.Han Jianlin[Identification of Y chromosome genetic variations in Chinese indigenous horse breeds]Identification of Y chromosome genetic variations in Chinese indigenous horse breeds

In order to investigate the genetic differentiation, we studied the genetic structure and genetic variation of 23 Chinese indigenous horse breeds and one thoroughbred horse population using 25 microsatellite markers. The number of alleles, polymorphism information content (PIC) and heterozygosity...


Yinghui, L.Yuejiao, C.Yanping, W.Weijun, GuanBaoling, F.Qian-Jun ZhaoXiaohong, H.Yabin PuYue-Hui MaHan Jianlin[Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers]Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers

Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel b...


Xiaohong HeXiaofei ChenWenbin ZhangYabin PuShen SongHan JianlinKunzhe DongQian-Jun ZhaoWeijun, GuanYuehui MaLin Jiang[High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)]High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)

Desmoglein 4 (DSG4) plays an important role in the regulation of growth and differentiation of hair follicles in mammals. In this study, a 755 bp long segment of DSG4 was screened in 544 sheep sampled from nine Chinese indigenous breeds and two Western breeds using PCR-SSCP assay with three diffe...


Yue-Hui MaGe, ZhangYuan-yue, ZhangWeijun, GuanQian-Jun ZhaoHui-jing, ZhaoHan Jianlin[Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium]Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium

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