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Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Available data indicate that CD8+ T lymphocyte res...


Pelle, RogerGraham, S.P.Njahira, Moses N.Osaso, J.Saya, R.M.Odongo, David O.Toye, Philip G.Spooner, P.R.Musoke, A.J.Mwangi, D.M.Taracha, E.L.N.Morrison, W. IvanWeir, W.Silva, J.Bishop, Richard P.[Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity]Two Theileria parva CD8 T Cell Antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity

An infection and treatment protocol is used to vaccinate cattle against Theileria parva infection. Due to incomplete cross-protection between different parasite isolates, a mixture of three isolates, termed the Muguga cocktail, is used for vaccination. While vaccination of cattle in some regions ...


Hemmink, J.D.Weir, W.MacHugh, Niall D.Graham, S.P.Patel, EktaPaxton, E.Shiels, B.Toye, Philip G.Morrison, W. IvanPelle, Roger[Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva]Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva

Many individual hosts are infected with multiple parasite species, and this may increase or decrease the pathogenicity of the infections. This phenomenon is termed heterologous reactivity and is potentially an important determinant of both patterns of morbidity and mortality and of the impact of ...


Woolhouse, Mark E.J.Thumbi, S.M.Jennings, A.Chase-Topping, M.Callaby, R.Kiara, Henry K.Oosthuizen, M.C.Mbole-Kariuki, Mary N.Conradie, I.Handel, I.G.Poole, Elizabeth J.Njiiri, E.Collins, N.E.Murray, G.Tapio, M.Auguet, O.T.Weir, W.Morrison, W. IvanKruuk, L.E.B.Bronsvoort, B.M. de C.Hanotte, Olivier H.Coetzer, K.Toye, Philip G.[Co-infections determine patterns of mortality in a population exposed to parasite infection]Co-infections determine patterns of mortality in a population exposed to parasite infection

African Cape buffalo (Syncerus caffer) is the wildlife reservoir of multiple species within the apicomplexan protozoan genus Theileria, including Theileria parva which causes East coast fever in cattle. A parasite, which has not yet been formally named, known as Theileria sp. (buffalo) has been r...


Bishop, Richard P.Hemmink, W.I.Morrison, J.D.Weir, W.Toye, Philip G.Sitt, T.Spooner, P.R.Musoke, A.J.Skilton, Robert A.Odongo, David O.[The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes]The African buffalo parasite Theileria. sp. (buffalo) can infect and immortalize cattle leukocytes and encodes divergent orthologues of Theileria parva antigen genes

Pain, A.Renauld, H.Berriman, M.Murphy, L.Yeats, C.A.Weir, W.Kerhornou, A.Aslett, M.Bishop, Richard P.Bouchier, C.Cochet, M.Coulson, R.M.R.Cronin, A.Villiers, Etienne P. deFraser, A.Fosker, N.Gardner, M.Goble, A.Griffiths-Jones, S.Harris, D.E.Katzer, F.Larke, N.Lord, A.Maser, P.McKellar, S.Mooney, P.Morton, F.Nene, VishvanathO'Neil, S.Price, C.Quail, M.A.Rabbinowitsch, E.Rawlings, N.D.Rutter, S.Saunders, D.Seeger, K.Shah, TushaarSquares, R.Squares, S.Tivey, A.Walker, A.R.Woodward, J.Dobbelaere, D.A.E.Langsley, G.Rajandream, M.A.McKeever, Declan J.Shiels, B.Tait, A.Barrell, B.Hall, N.[Genome of the host-cell transforming parasite Theileria annulata compared with T. parva]Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

The published genomic sequences of the two major host-transforming Theileria species of cattle represent a rich resource of information that has allowed novel bioinformatic and experimental studies into these important apicomplexan parasites. Since their publication in 2005, the genomes of T. ann...


Weir, W.Sunter, J.Chaussepied, M.Skilton, Robert A.Tait, A.Villiers, Etienne P. deBishop, Richard P.Shiels, B.Langsley, G.[Highly syntenic and yet divergent: a tale of two Theilerias]Highly syntenic and yet divergent: a tale of two Theilerias
Sitt, T.Pelle, RogerWeir, W.Steinaa, LucillaMorrison, W. IvanToye, Philip G.[Genotypic and antigenic diversity of Theileria parva in buffalo and buffalo-associated cattle]Genotypic and antigenic diversity of Theileria parva in buffalo and buffalo-associated cattle
Pain, A.Renauld, H.Berriman, M.Murphy, L.Yeats, C.A.Weir, W.Kerhornou, A.Aslett, M.Bishop, Richard P.Bouchier, C.Bouchier, C.Cochet, M.Coulson, R.M.R.Cronin, A.Villiers, Etienne P. deFraser, A.Fosker, N.Gardner, M.Goble, A.Griffiths-Jones, S.Harris, D.E.Katzer, F.Larke, N.Lord, A.Maser, P.McKellar, S.Mooney, P.Morton, F.Nene, VishvanathO'Neil, S.Price, C.Quail, M.A.Rabbinowitsch, E.Rawlings, N.D.Rutter, S.Saunders, D.Seeger, K.Shah, TushaarSquares, R.Squares, S.Tivey, A.Walker, A.R.Woodward, J.Dobbelaere, D.A.E.Langsley, G.Rajandream, M.A.McKeever, Declan J.Shiels, B.Tait, A.Barrell, B.Hall, N.[Genome of the host-cell transforming parasite Theileria annulata compared with T. parva]Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
Sitt, T.Pelle, RogerWeir, W.Steinaa, LucillaShiels, B.Morrison, W. IvanToye, Philip G.[Theileria parva: Genotypic and antigenic diversity in buffalo and buffalo-associated cattle]Theileria parva: Genotypic and antigenic diversity in buffalo and buffalo-associated cattle

Hayashida, K.Hara, Y.Abe, T.Yamasaki, C.Toyoda, A.Kosuge, T.Suzuki, Y.Sato, Y.Kawashima, S.Katayama, T.Wakaguri, H.Inoue, N.Homma, K.Tada-Umezaki, M.Yagi, Y.Fujii, Y.Habara, T.Kanehisa, M.Watanabe, H.Ito, K.Gojobori, T.Sugawara, H.Imanishi, T.Weir, W.Gardner, M.Pain, A.Shiels, B.Hattori, M.Nene, VishvanathSugimoto, C.[Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformation]Comparative genome analysis of three eukaryotic parasites with differing abilities to transform leukocytes reveals key mediators of Theileria-induced leukocyte transformation

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