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Zoller, T.Fèvre, Eric M.Welburn, S.C.Odiit, M.Coleman, P.G.[Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda]Analysis of risk factors for T. brucei rhodesiense sleeping sickness within villages in south-east Uganda

Bloodstream forms (BSF) and procyclic culture forms (PCF) of African trypanosomes were incubated with a variety of lectins in vitro. Cessation of cell division and profound morphological changes were seen in procyclic forms but not in BSF after incubation with concanvavalin A (Con A). Wheat germ...


Pearson, T.W.Beecroft, R.P.Welburn, S.C.Ruepp, S.Roditi, I.Kuo-Yuan, H.Englund, P.T.Wells, C.W.Murphy, N.B.[The major cell surface glycoprotein procycline is a receptor for induction of a novel form of cell death in African trypanosomes in vitro]The major cell surface glycoprotein procycline is a receptor for induction of a novel form of cell death in African trypanosomes in vitro

Many parasite species are known to show high levels of genetic diversity, yet the consequences of this diversity for host-parasite interactions are not well understood. Variation in phenotypic traits such as growth rates and the ability to form transmission stages are raw material for natural a...


Taylor, L.H.Katzer, F.Shiels, B.R.Welburn, S.C.[Genetic and phenotypic analysis of Tunisian Theileria annulata clones]Genetic and phenotypic analysis of Tunisian Theileria annulata clones

This paper is a review of the meeting "Sleeping Sickness Rediscovered". The meeting focussed on human sleeping sickness, which, despite improvements in diagnosis and control has returned with a vengeance across central Africa. Topics of discussion include control activities; control tools; resear...


Welburn, S.C.Fèvre, Eric M.Coleman, P.[Sleeping sickness rediscovered]Sleeping sickness rediscovered
Fèvre, Eric M.Wissmann, B.V.Welburn, S.C.Lutumba, P.[The burden of human African trypanosomiasis]The burden of human African trypanosomiasis

Ixodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs ...


Lambson, B.Nene, VishvanathObura, M.Shah, TushaarPandit, P.Ole-MoiYoi, O.K.Delroux, K.Welburn, S.C.Skilton, Robert A.Villiers, Etienne P. deBishop, Richard P.[Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells]Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells

Procyclic Trypanosoma brucei rhodesiense have a cell death mechanism which can be activated by an external signal, the lectin ConA, in vitro. ConA has been shown to cause profound changes in cellular morphology and induce fragmentation of nuclear DNA in T.b. rhodesiense which are characteristic o...


Murphy, N.B.Welburn, S.C.[Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs]Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs

Background: The expansion of sleeping sickness caused by Trypanosoma brucei rhodesiense (T. rhodesiense) beyond its traditional focus in southeast Uganda, has been linked with large-scale livestock restocking. To assess the risk presented to the human population by domestic livestock, human-infe...


Welburn, S.C.Picozzi, K.Fèvre, Eric M.Coleman, P.G.Odiit, M.Carrington, M.Maudlin, I.[Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene]Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene

Background Human brucellosis has been found to be prevalent in the urban areas of Kampala, the capital city of Uganda. A cross-sectional study was designed to generate precise information on the prevalence of brucellosis in cattle and risk factors for the disease in its urban and peri-urban dairy...


Makita, K.Fèvre, Eric M.Waiswa, C.Eisler, M.C.Thrusfield, M.V.Welburn, S.C.[Herd prevalence of bovine brucellosis and analysis of risk factors in cattle in urban and peri-urban areas of the Kampala economic zone, Uganda]Herd prevalence of bovine brucellosis and analysis of risk factors in cattle in urban and peri-urban areas of the Kampala economic zone, Uganda

In developing countries, cities are rapidly expanding and urban and peri-urban agriculture (UPA) has an important role in feeding these growing urban populations; however such agriculture also carries public health risks such as zoonotic disease transmission. It is important to assess the role of...


Makita, K.Fèvre, Eric M.Waiswa, C.Bronsvoort, B.M. de C.Eisler, M.C.Welburn, S.C.[Population-dynamics focussed rapid rural mapping and characterization of the peri-urban interface of Kampala, Uganda]Population-dynamics focussed rapid rural mapping and characterization of the peri-urban interface of Kampala, Uganda

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