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The QM protein has been reported to have roles in both tumour suppression and transcription factor regulation in vertebrate cells, and in ribosome stability in both yeast and mammals. The present study isolated the QM gene of Trypanosoma brucei and determined its sequence. Alignment with QM seque...


Lillico, S.G.Mottram, J.C.Murphy, N.B.Welburn, S.C.[Characterisation of the QM gene of Trypanosoma brucei]Characterisation of the QM gene of Trypanosoma brucei

We have carried out a study of risk factors for early detection of Trypanosoma brucei rhodesiense sleeping sickness. Records of sleeping sickness patients from 1987 to 2001 from Tororo and Busia districts in Uganda were reviewed for their village of origin and clinical stage (early or late). All...


Odiit, M.Coleman, P.G.McDermott, John J.Fèvre, Eric M.Welburn, S.C.Woolhouse, Mark E.J.[Spatial and temporal risk factors for the early detection of Trypanosoma brucei rhodesiense sleeping sickness patients in Tororo and Busia districts, Uganda]Spatial and temporal risk factors for the early detection of Trypanosoma brucei rhodesiense sleeping sickness patients in Tororo and Busia districts, Uganda

Procyclic Trypanosoma brucei rhodesiense have a cell death mechanism which can be activated by an external signal, the lectin ConA, in vitro. ConA has been shown to cause profound changes in cellular morphology and induce fragmentation of nuclear DNA in T.b. rhodesiense which are characteristic o...


Murphy, N.B.Welburn, S.C.[Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs]Programmed cell death in procyclic Trypanosoma brucei rhodesiense is associated with differential expression of mRNAs

Background: The expansion of sleeping sickness caused by Trypanosoma brucei rhodesiense (T. rhodesiense) beyond its traditional focus in southeast Uganda, has been linked with large-scale livestock restocking. To assess the risk presented to the human population by domestic livestock, human-infe...


Welburn, S.C.Picozzi, K.Fèvre, Eric M.Coleman, P.G.Odiit, M.Carrington, M.Maudlin, I.[Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene]Identification of human-infective trypanosomes in animal reservoir of sleeping sickness in Uganda by means of serum-resistance-associated (SRA) gene

To formally quantify the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness (SS) during an epidemic in Uganda, a decision tree (under-detection) model was developed; concurrently, to quantify the subset of undetected cases that sought health care but were not diagnosed, ...


Odiit, M.Coleman, P.G.Liu, W.C.McDermott, John J.Fèvre, Eric M.Welburn, S.C.Woolhouse, Mark E.J.[Quantifying the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness cases]Quantifying the level of under-detection of Trypanosoma brucei rhodesiense sleeping sickness cases

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