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A live, attenuated vaccine is currently the only viable option to control of CBPP in Africa. It has been suggested that simple modifications to current vaccines and protocols might improve efficacy in the field. In this report we compared the current vaccine formulation with a buffered preparatio...


Nkando, I.Ndinda, J.Kuria, J.Naessens, JanMbithi, F.Schnier, C.Gicheru, M.McKeever, Declan J.Wesonga, H.O.[Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle]Efficacy of two vaccine formulations against contagious bovine pleuropneumonia (CBPP) in Kenyan indigenous cattle

Mycoplasma mycoides subsp. mycoides (Mmm) is the causative agent of contagious bovine pleuropneumonia (CBPP), a severe pleuropneumonia in cattle. The abnormal accumulation of pleural fluid, called pleural effusion (PE), is one of the characteristics of this disease. We performed a proteomic analy...


Weldearegay, Yenehiwot BerhanuPich, AndreasSchieck, Elise G.Liljander, Anne M.Gicheru, N.Wesonga, H.O.Thiaucourt, FrancoisKiirika, L.M.Valentin-Weigand, PeterJores, JoergMeens, J.[Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP)]Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP)

Contagious bovine pleuropneumonia (CBPP) is one of the most important transboundary animal diseases in Africa. In recent years, CBPP has been found in countries like Botswana from where it was previously eradicated (Amanfu et al., 1998). There is growing evidence to indicate that the incidence of...


Mbithi, F.Wesonga, H.O.Thiaucourt, FrancoisTaracha, E.L.N.[Immune responses in cattle vaccinated against contagious bovine pleuropneumonia: preliminary results]Immune responses in cattle vaccinated against contagious bovine pleuropneumonia: preliminary results

The membrane-associated enzyme l-α-glycerol-3-phosphate oxidase (GlpO) of Mycoplasma mycoides subs. mycoides (Mmm), the causal agent of contagious bovine pleuropneumonia (CBPP) has been identified as a virulence factor responsible for the release of toxic by-products such as H2O2 that mediate hos...


Mulongo, M.M.Frey, J.Smith, K.Schnier, C.Wesonga, H.O.Naessens, JanMcKeever, Declan J.[Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge]Cattle immunized against the pathogenic l-α-glycerol-3-phosphate oxidase of Mycoplasma mycoides subs. mycoides in cattle fail to generate neutralizing antibodies and succumb to disease on challenge

Current contagious bovine pleuropneumonia (CBPP) vaccines are based on live-attenuated strains of Mycoplasma mycoides subsp. mycoides (Mmm). These vaccines have shortcomings in terms of efficacy, duration of immunity and in some cases show severe side effects at the inoculation site; hence the ne...


Pérez Casal, J.Prysliak, T.Maina, T.Wang, Y.Townsend, H.Berverov, E.Nkando, I.Wesonga, H.O.Liljander, Anne M.Jores, JoergNaessens, JanGerdts, V.Potter, A.[Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia]Analysis of immune responses to recombinant proteins from strains of Mycoplasma mycoides subsp. mycoides, the causative agent of contagious Bovine pleuropneumonia
Lutta, H.O.Mather, A.Maina, T.W.Odongo, D.Ndiwa, Nicholas N.Wesonga, H.O.Naessens, Jan[Preliminary findings of lipoprotein B in detecting cattle chronically infected with contagious bovine pleuropneumonia]Preliminary findings of lipoprotein B in detecting cattle chronically infected with contagious bovine pleuropneumonia

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