Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the de...
Williams, D.J.L.
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Taylor, K.
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Wilkie, B.
,
Gichuki, B.
,
Authié, E.
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[Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle]
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Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle
Sileghem, M.R.
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Saya, R.
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Ellis, J.
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Flynn, J.N.
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Peel, J.E.
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Williams, D.J.L.
,
[Detection and neutralization of bovine tumor necrosis factor by a monoclonal antibody]
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Detection and neutralization of bovine tumor necrosis factor by a monoclonal antibody
Authié, E.
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Duvallet, G.
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Robertson, C.
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Williams, D.J.L.
,
[Antibody response to a 33 kDa cysteine protease of Trypanosoma congolense: Relationship to 'trypanotolerance' in cattle]
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Antibody response to a 33 kDa cysteine protease of Trypanosoma congolense: Relationship to 'trypanotolerance' in cattle
Trypanotolerance involves an ability to both control trypanosome multiplication and resist the pathogenic effects of trypanosome infection. Studies in the African Trypanotolerant Livestock Network and elsewhere have shown that the latter capacity is more closely correlated than the former to the ...
Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (...
Lutje, V.
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Authié, E.
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Boulange, A.F.
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Williams, D.J.L.
,
[Bovine T-cell responses to defined Trypanosoma congolense antigens during infection]
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Bovine T-cell responses to defined Trypanosoma congolense antigens during infection
Analysis of serum antibody responses in cattle experimentally infected with Trypanosoma congolense suggested that antibody responses of trypanosusceptible Boran cattle are less efficient in isotype switching and affinity maturation than those of trypanotolerant N'Dama cattle. High levels of polys...
The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a parti...
Williams, D.J.L.
,
Taylor, K.
,
Newson, J.
,
Naessens, Jan
,
Authié, E.
,
[Protective and inappropriate antibody responses in trypanosome-infected cattle]
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Protective and inappropriate antibody responses in trypanosome-infected cattle