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Flynn, J.N.Sileghem, M.R.Williams, D.J.L.[Parasite-specific T-Cell response of trypanotolerant and trypanosusceptible cattle during infection with Trypanosoma congolense]Parasite-specific T-Cell response of trypanotolerant and trypanosusceptible cattle during infection with Trypanosoma congolense
Williams, D.J.L.Naessens, JanMoloo, S.K.Scott, J.R.[Analysis of peripheral blood leukocyte populations in N'Dama and Boran cattle following Glossina morsitans centralis-transmitted Trypanosoma congolense infection]Analysis of peripheral blood leukocyte populations in N'Dama and Boran cattle following Glossina morsitans centralis-transmitted Trypanosoma congolense infection

Trypanotolerance involves an ability to both control trypanosome multiplication and resist the pathogenic effects of trypanosome infection. Studies in the African Trypanotolerant Livestock Network and elsewhere have shown that the latter capacity is more closely correlated than the former to the ...


Authié, E.Boulange, A.F.Muteti, D.Taylor, K.A.Williams, D.J.L.[Antibody responses to invariant antigens of Trypanosoma congolense]Antibody responses to invariant antigens of Trypanosoma congolense

Infections of cattle with tsetse-transmitted Trypanosoma congolense are accompanied by antibody responses to the variable surface glycoprotein (VSG) and to two major invariant antigens, a member of the hsp 70 family and a 33KDa cysteine protease. During primary infection, trypanotolerant N'Dama (...


Lutje, V.Authié, E.Boulange, A.F.Williams, D.J.L.[Bovine T-cell responses to defined Trypanosoma congolense antigens during infection]Bovine T-cell responses to defined Trypanosoma congolense antigens during infection

Analysis of serum antibody responses in cattle experimentally infected with Trypanosoma congolense suggested that antibody responses of trypanosusceptible Boran cattle are less efficient in isotype switching and affinity maturation than those of trypanotolerant N'Dama cattle. High levels of polys...


Taylor, K.A.Williams, D.J.L.Lutje, V.[B-cell activation in trypanosome-infected Boran cattle]B-cell activation in trypanosome-infected Boran cattle

The trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a parti...


Williams, D.J.L.Taylor, K.Newson, J.Naessens, JanAuthié, E.[Protective and inappropriate antibody responses in trypanosome-infected cattle]Protective and inappropriate antibody responses in trypanosome-infected cattle

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