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Trypanosomes are covered with a dense layer of antigenically identical glycoproteins. These molecules are highly immunogenic and elicit an antibody response in the infected host. Antibodies against the surface-exposed epitopes of the trypanosome variable surface glycoproteins (VSG) mediate the de...


Williams, D.J.L.Taylor, K.Wilkie, B.Gichuki, B.Authié, E.[Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle]Antibody responses to the surface-exposed epitopes of the trypanosome variable surface glycoprotein in N'Dama and Boran cattle

A bioassay was used to measure erythropoietin (EPO) concentrations in calves with haemorrhagic anaemia due to blood loss and in calves with anaemia due to Trypanosoma congolense infection. The bioactivity of EPO was measured in the assay by its stimulatory effect on 125I-deoxyuridine incorporatio...


Buza, J.J.Logan-Henfrey, L.L.Andrianarivo, A.G.Williams, D.J.L.[Rise in erythropoietin concentrations in experimental Trypanosoma congolense infection of calves]Rise in erythropoietin concentrations in experimental Trypanosoma congolense infection of calves

It has been reported that some breeds of cattle such as the N'Dama mount a more effective antibody response to the variable surface glycoprotein coat of trypanosomes and that this may contribute to their ability to control the infection. Thus we have investigated antibody responses to surface exp...


Williams, D.J.L.Taylor, K.Newson, J.Gichuki, B.Naessens, Jan[The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance]The role of anti-variable surface glycoprotein antibody responses in bovine trypanotolerance
Dwinger, R.H.Grieve, S.Snow, W.F.Rawlings, P.Jabang, B.Williams, D.J.L.[Maternal antibodies in N'Dama calves kept under natural trypanosomiasis risk in the Gambia]Maternal antibodies in N'Dama calves kept under natural trypanosomiasis risk in the Gambia

Analysis of serum antibody responses in cattle experimentally infected with Trypanosoma congolense suggested that antibody responses of trypanosusceptible Boran cattle are less efficient in isotype switching and affinity maturation than those of trypanotolerant N'Dama cattle. High levels of polys...


Taylor, K.A.Williams, D.J.L.Lutje, V.[B-cell activation in trypanosome-infected Boran cattle]B-cell activation in trypanosome-infected Boran cattle

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