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Sheep has successfully adapted to the extreme high-altitude Himalayan region. To identify genes underlying such adaptation, we genotyped genome-wide single nucleotide polymorphisms (SNPs) of four major sheep breeds living at different altitudes in Nepal and downloaded SNP array data from addition...


Gorkhali, N.A.Kunzhe DongMin YangShen SongKader, A.Shrestha, B.S.Xiaohong HeQian-Jun ZhaoYabin PuXiangchen LiKijas, J.Weijun, GuanHan JianlinLin JiangYuehui Ma[Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas]Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas

MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...


Qian-Jun ZhaoYe KangHong-Yang WangWeijun, GuanXiang-Chen LiLin JiangXiao-Hong HeYabin PuHan JianlinYue-Hui MaQian-Jun Zhao[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development

In order to investigate the genetic differentiation, we studied the genetic structure and genetic variation of 23 Chinese indigenous horse breeds and one thoroughbred horse population using 25 microsatellite markers. The number of alleles, polymorphism information content (PIC) and heterozygosity...


Yinghui, L.Yuejiao, C.Yanping, W.Weijun, GuanBaoling, F.Qian-Jun ZhaoXiaohong, H.Yabin PuYue-Hui MaHan Jianlin[Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers]Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers

Heteroplasmy is the presence of more than one mitochondrial DNA (mtDNA) variant within a cell, tissue, or individual. In this study, sequence variation was investigated in the control region (CR) of mitochondrial DNA (mtDNA) from 135 individuals belonging to five primary domestic Bactrian camel b...


Xiaohong HeXiaofei ChenWenbin ZhangYabin PuShen SongHan JianlinKunzhe DongQian-Jun ZhaoWeijun, GuanYuehui MaLin Jiang[High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)]High occurrence of length heteroplasmy in domestic Bactrian camel (Camelus bactrianus)
Xuexue LiuYanli ZhangYefang LiJianfei PanDandan WangWeihuang ChenZhuqing ZhengXiaohong HeQianjun ZhaoYabin PuWeijun GuanHan JianlinLudovic OrlandoYuehui MaLin Jiang[EPAS1 gain-of-function mutation contributes to high altitude adaptation in Tibetan horses]EPAS1 gain-of-function mutation contributes to high altitude adaptation in Tibetan horses

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