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Heteroplasmy due to length polymorphism with tandem repeats in mtDNAs within individual was hardly studied in domestic animals. In the present study, we identified intra-individual length variation in the control region of mtDNAs in Nepalese sheep by molecular cloning and sequencing techniques. W...


Gorkhali, N.A.Lin JiangShrestha, B.S.Xiao-Hong HeQian-Jun ZhaoHan JianlinYue-Hui Ma[High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep]High occurrence of mitochondrial heteroplasmy in nepalese indigenous sheep (Ovis aries) compared to chinese sheep

MicroRNAs (miRNAs) are evolutionarily conserved, small, non-coding RNAs that have emerged as key regulators of myogenesis. Here, we examined the miRNA expression profiles of developing sheep skeletal muscle using a deep sequencing approach. We detected 2,396 miRNAs in the sheep skeletal muscle ti...


Qian-Jun ZhaoYe KangHong-Yang WangWeijun, GuanXiang-Chen LiLin JiangXiao-Hong HeYabin PuHan JianlinYue-Hui MaQian-Jun Zhao[Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development]Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development

Y chromosome acts as a single nonrecombining unit that is male specific and in effect haploid, thus ensuring the preservation of mutational events as a single haplotype via male lines. In this study, 6 Y chromosome–specific microsatellites (SSR) were tested for the patrilineal genetic variations ...


Yinghui, LingYue-Hui MaWeijun, GuanYuejiao, ChengYanping, WangDapeng, J.Lai, M.Halik, M.Han Jianlin[Identification of Y chromosome genetic variations in Chinese indigenous horse breeds]Identification of Y chromosome genetic variations in Chinese indigenous horse breeds

In order to investigate the genetic differentiation, we studied the genetic structure and genetic variation of 23 Chinese indigenous horse breeds and one thoroughbred horse population using 25 microsatellite markers. The number of alleles, polymorphism information content (PIC) and heterozygosity...


Yinghui, L.Yuejiao, C.Yanping, W.Weijun, GuanBaoling, F.Qian-Jun ZhaoXiaohong, H.Yabin PuYue-Hui MaHan Jianlin[Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers]Genetic diversity of 23 Chinese indigenous horse breeds revealed by microsatellite markers

To understand the origin and genetic phylogeography of Chinese black goats, variations of mitochondrial DNA were characterised with 394 goats from 18 breeds, including 91 new individuals from regions poorly studied until now. Comparison of a 481-bp segment revealed a total of 192 haplotypes with ...


Tao ZhongQian-Jun ZhaoLi Li NiuJie WangPeng Fei JinWei ZhaoLin Jie WangLi LiHong Ping ZhangYue-Hui Ma[Genetic phylogeography and maternal lineages of 18 Chinese black goat breeds]Genetic phylogeography and maternal lineages of 18 Chinese black goat breeds

Desmoglein 4 (DSG4) plays an important role in the regulation of growth and differentiation of hair follicles in mammals. In this study, a 755 bp long segment of DSG4 was screened in 544 sheep sampled from nine Chinese indigenous breeds and two Western breeds using PCR-SSCP assay with three diffe...


Yue-Hui MaGe, ZhangYuan-yue, ZhangWeijun, GuanQian-Jun ZhaoHui-jing, ZhaoHan Jianlin[Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium]Six SNPs and a TTG indel in sheep desmoglein 4 gene are in complete linkage disequilibrium

Despite much attention, history of sheep (Ovis aries) evolution, including its dating, demographic trajectory and geographic spread, remains controversial. To address these questions, we generated 45 complete and 875 partial mitogenomic sequences, and performed a meta-analysis of these and publis...


Feng-Hua LvWei-Feng PengJi YangYong-Xin ZhaoWen-Rong LiMing-Jun LiuYue-Hui MaQian-Jun ZhaoGuang-Li YangFeng WangJin-Quan LiYong-Gang LiuZhi-Qiang ShenSheng-Guo ZhaoEEr HehuaGorkhali, N.A.Farhad Vahidi, S.M.Muladno, M.Naqvi, A.N.Tabell, J.Iso-Touru, T.Bruford, M.W.Kantanen, J.Han JianlinMeng-Hua Li[Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep]Mitogenomic meta-analysis identifies two phases of migration in the history of Eastern Eurasian sheep

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