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International Laboratory for Research on Animal Diseases[ILRAD Reports. Volume 11. Number 4. October 1993]ILRAD Reports. Volume 11. Number 4. October 1993

Trypanosomosis is the most economically important disease constraint to livestock productivity in sub-Saharan Africa and has significant negative impact in other parts of the world. Livestock are an integral component of farming systems and thus contribute significantly to food and economic secur...


Taylor, K.A.Mertens, B.[Immune responses of cattle to African trypanosomes: Protective or pathogenic?]Immune responses of cattle to African trypanosomes: Protective or pathogenic?

The tumor necrosis factor (TNF) locus comprises the tandemly arranged genes coding for Tnfa (cachectin)and Tnfb (lymphotoxin-alpha) (Semon et al. 1987). In mice, the TNF locus is located on chromosome 17 (MMU17) in the major histocompatibility complex (MHC)region. Tnfa and soluble lymphotoxin alp...


Iraqi, F.A.Teale, A.J.[Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice]Polymorphisms in the TNFa but not in TNFb microsatellite and correlation with trypanosomiasis in mice

Theileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of ...


Houston, E.F.Taracha, E.L.N.Brackenbury, L.MacHugh, Niall D.McKeever, Declan J.Charleston, B.Morrison, W. Ivan[Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function]Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function

Tumor necrosis factor-[alpha] (TNF-[alpha]) plays a role in the host's defence against infections with African trypanosomes. It helps to control the blood stream form of the parasite and in Trypanosoma congolense infections, it also prolongs survival. The mechanisms by which this cytokine can inf...


Kitani, H.Yagi, Y.Naessens, JanSekikawa, K.Iraqi, F.A.[The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene]The secretion of acute phase proteins and inflammatory cytokines during Trypanosoma congolense infection is not affected by the absence of the TNF-[alpha] gene
Young, A.S.Cummins, J.M.Orinda, G.O.Wright, I.G.[Cytokines in tick-borne protozoal infections and their use in therapy]Cytokines in tick-borne protozoal infections and their use in therapy

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