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Young, A.S.Koech, D.K.[Biological response modifiers: Cytokines in health and disease and their therapeutic value]Biological response modifiers: Cytokines in health and disease and their therapeutic value

An isolate of T. vivax was collected from a naturally infected Zebu in French Guyana. The isolate was subsequently shown to produce pathogenic infections in both Taurine and Zebu cattle. However, its sensitivity of the population to diminazene aceturate and isometamidium chloride was determined s...


Desquesnes, M.Rocque, S. de laPeregrine, A.S.[French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride]French Guyanan stock of Trypanosoma vivax resistant to diminazene aceturate but sensitive to isometamidium chloride
Kaminsky, R.Mamman, M.Chuma, FrancisZweygarth, E.[Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenir) and in vitro simulation of drug-concentration-time profiles in cattle plasma]Time-dose-response of Trypanosoma brucei brucei to diminazene aceturate (Berenir) and in vitro simulation of drug-concentration-time profiles in cattle plasma

Experiments were carried out in goats to determine the frequency with which diminazene-resistant trypanosomes occur in parasite populations before and after the intramuscular treatment of the goats with diminazene aceturate. Trypanosoma congolense IL3274, a diminazene-resistant clone, was used to...


Mamman, M.Williams, D.J.L.Murphy, N.B.Peregrine, A.S.[Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense]Apparent rarity of diminazene-resistant trypanosomes in goats infected with a diminazene-resistant population of Trypanosoma congolense

In 1986 a project was set up to determine the constraints to production of Zebu cattle under trypanosomiasis risk in the Ghibe valley. Approximately 1800 East African Zebu cattle (EAZC) were resident within the Ghibe valleey during the experimental period (1986 - 1992) and were maintained under t...


Peregrine, A.S.Mulatu, W.Leak, S.G.A.Rowlands, G.J.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control

This paper is a review of the meeting "Sleeping Sickness Rediscovered". The meeting focussed on human sleeping sickness, which, despite improvements in diagnosis and control has returned with a vengeance across central Africa. Topics of discussion include control activities; control tools; resear...


Welburn, S.C.Fèvre, Eric M.Coleman, P.[Sleeping sickness rediscovered]Sleeping sickness rediscovered

In a tsetse-infested area of Kenya, we characterised veterinary-drug outlets based on personnel and business characteristics to assess their capacities to provide clinical veterinary services. Structured questionnaires were administered to the retailers and sought information on the characterist...


Bett, Bernard K.Machila, N.Gathura, P.B.McDermott, John J.Eisler, M.C.[Characterisation of shops selling veterinary medicines in a tsetse-infested area of Kenya]Characterisation of shops selling veterinary medicines in a tsetse-infested area of Kenya

During this century livestock production has increased massively through the improved ability to diagnose, treat, control and prevent certain diseases. Despite these advances, disease remains a major constraint to livestock production and welfare throughout the world. In many instances, this is a...


Gu, Y.Gettinby, G.McKendrick, I.Murray, M.Peregrine, A.S.[Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa]Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa

The relationship between serum concentrations of the prophylactic trypanocidal drug isometamidium chloride and protection against tsetse challenge with two populations of Trypanosoma congolense was investigated in Boran (Bos indicus) cattle, using an isometamidium-ELISA. Isometamidium chloride (S...


Eisler, M.C.Gault, E.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense]Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense

Six Boran cattle were infected with the drug-resistant Trypanosoma congolense IL 3338. At the first peak of parasitemia different groups of 200 teneral Glossina morsitans centralis were fed once on each animal, just prior to treatment with diminazene aceturate at a dose of 3.5 mg kg-1 body weight...


Diack, A.Moloo, S.K.Peregrine, A.S.[Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis]Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis

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