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Sensitivity and specificity of the FAO/IAEA kits for diagnosis of bovine trypanosomosis were investigated using sera from experimental cattle infected by tsetse challenge with cloned populations of Trypanosoma congolense (three populations) or T. vivax (one population). The kits are based on mono...


Eisler, M.C.Lessard, P.Masake, R.A.Moloo, S.K.Peregrine, A.S.[Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypansoma vivax infections in cattle]Sensitivity and specificity of antigen-capture ELISAs for diagnosis of Trypanosoma congolense and Trypansoma vivax infections in cattle

Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...


Kemp, Stephen J.Teale, A.J.[Genetic basis of trypanotolerance in cattle and mice]Genetic basis of trypanotolerance in cattle and mice

Ribosomal RNA genes have been cloned from the major species of African trypanosomes. Complete nucleotide sequence composition of the small subunit (SSU) and portions of the large subunit (LSU) ribosomal RNA genes was determined for each of these trypanosome species. In contrast to the situation i...


Urakawa, T.Majiwa, P.A.O.[Physical and transcriptional organization of the ribosomal RNA genes of the savannah-type Trypanosoma congolense]Physical and transcriptional organization of the ribosomal RNA genes of the savannah-type Trypanosoma congolense

The pathogenic trypanosomes Trypanosoma vivax and Trypanosoma congolense are transmitted by tsetse and cause trypanosomosis, a debilitating disease affecting livestock in Africa and South America. Here, we discuss the need, relevance and advantage of having the Trypanosoma genomes sequenced, an...


Davila, A.M.R.Majiwa, P.A.O.Grisard, E.C.Aksoy, S.Melville, S.E.[Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes]Comparative genomics to uncover the secrets of tsetse and livestock-infective trypanosomes

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection
Mamman, M.Gettinby, G.Murphy, N.B.Kemei, S.Peregrine, A.S.[Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene]Frequency of diminazene-resistant trypanosomes in populations of Trypanosoma congolense arising in infected animals following treatment with diminazene

African trypansosomes are tsetse-transmitted parasites of chief importance in causing disease in livestock in regions of sub-Saharan Africa. Previous studies have demonstrated that certain breeds of cattle are relatively resistant to infection with trypanosomes, and others are more susceptible. B...


Haas, K.M.Taylor, K.A.MacHugh, Niall D.Kreeger, J.M.Estes, D.M.[Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection]Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection

Discusses trypanotolerance in cattle and prospects for the control of trypanosomiasis by selective breeding in Africa. Looks into methods available for control including tsetse control, drugs & vaccination and discusses constraints that limit the control. Also discusses prospects for future contr...


Murray, M.Trail, J.C.M.D'Ieteren, G.D.M.[Trypanotolerance in cattle and prospects for the control of trypanosomiasis by selective breeding]Trypanotolerance in cattle and prospects for the control of trypanosomiasis by selective breeding

Polymerase chain reaction (PCR) and deoxyribonucleic acid (DNA) probes were used to characterize trypanosomes from cattle in Morogoro region of Tanzania. Blood samples collected from 390 beef and dairy cattle in selected farms in Morogoro region were examined for presence of trypanosomes using th...


Mugittu, K.N.Silayo, R.S.Majiwa, P.A.O.Kimbita, E.K.Mutayoba, B.M.MaSelle, R.[Application of PCR and DNA probes in the characterisation of trypanosomes in the blood of cattle in farms in Morogoro, Tanzania]Application of PCR and DNA probes in the characterisation of trypanosomes in the blood of cattle in farms in Morogoro, Tanzania

Following an outbreak of trypanosomosis in horses on a farm in Kenya, 18 trypanosome isolates were collected from the infected animals over a period of one and a half years and cryopreserved for characterization. The characterization was done on the basis of morphology using Giemsa-stained blood ...


Kihurani, D.O.Masake, R.A.Nantulya, V.M.Mbiuki, S.M.[Characterization of trypanosome isolates from naturally infected horses on a farm in Kenya]Characterization of trypanosome isolates from naturally infected horses on a farm in Kenya

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