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There have been tremendous advances in our knowledge of trypanosome biology, yet many aspects remain unclear. Currently, the genome of Trypanosome brucei is being sequenced and this, with other genome-wide analysis methods, could provide novel insights into the parasite and facilitate the develop...


Agbo, E.C.Majiwa, P.A.O.Bascher, P.Claassen, E.Marinus, F.W.P.[Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets]Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets

Experimental infections of mice with the African trypanosome Trypanosoma brucei lead to a profound state of T-cell unresponsiveness in the lymph node cell (LNC) compartment. This suppression is mediated by macrophage-like cells which inhibit interleukin 2 (IL-2) secretion and down-regulate IL-2 r...


Darji, A.Beschin, A.Sileghem, M.R.Heremans, H.Brys, L.Baetselier, P. de[In vitro simulation of immuno-suppression caused by Trypanosoma brucei: Active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression]In vitro simulation of immuno-suppression caused by Trypanosoma brucei: Active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression
Shapiro, S.Z.Kimmel, E.[A simple method for the production of specific antiserum to protein encoded in cloned genes. Immunization with precipitin lines]A simple method for the production of specific antiserum to protein encoded in cloned genes. Immunization with precipitin lines

Cyclophilin A from the bovine parasite Trypanosoma brucei brucei has been cloned, expressed in Escherichia coli, purified and crystallized in the presence of cyclosporin A using ammonium sulfate as a precipitant. The crystals belong to the orthorhombic crystal system with unit-cell dimensions of ...


Dao-Thi, M.H.Transue, T.R.Pelle, RogerMurphy, N.B.Poortmans, F.Steyaert, J.[Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei]Expression, purification, crystalization and preliminary X-ray analysis of cyclophilin A from the bovine parasite Trypanosoma brucei brucei
Clarkson, A.B.Bienen, E.J.Pollakis, G.Saric, M.McIntosh, L.Grady, R.W.[Trypanosome alternative oxidase]Trypanosome alternative oxidase
Masake, R.A.Nantulya, V.M.Akol, G.W.O.Musoke, A.J.[Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and Trypanosoma brucei brucei infections]Cerebral trypanosomiasis in cattle with mixed Trypanosoma congolense and Trypanosoma brucei brucei infections
Moloo, S.K.Asonganyi, T.Jenni, L.[Cyclical development of Trypanosoma brucei gambiense from cattle and goats in Glossina]Cyclical development of Trypanosoma brucei gambiense from cattle and goats in Glossina
Borowy, N.K.Fink, E.Hirumi, H.[In vitro activity of the trypanocidal diamidine DAPI on animal-infective Trypanosoma brucei brucei]In vitro activity of the trypanocidal diamidine DAPI on animal-infective Trypanosoma brucei brucei
Kaminsky, R.Zweygarth, E.[The effect of verapamil alone and in combination with trypanocides on multidrug-resistant Trypanosoma brucei brucei]The effect of verapamil alone and in combination with trypanocides on multidrug-resistant Trypanosoma brucei brucei
Zweygarth, E.Kaminsky, R.[Evaluation of DL-alpha difluoromethylornithine against susceptible and drug-resistant Trypanosoma brucei brucei]Evaluation of DL-alpha difluoromethylornithine against susceptible and drug-resistant Trypanosoma brucei brucei

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