The nucleotide sequences of the large subunit ribosomal RNA coding genes within the two single copy ribosomal DNA transcription units of a cloned Theileria parva isolate from a buffalo were determined. The two LSU rRNA coding units differed by 11 nucleotide substitutions and two deletions of 1 an...
Bishop, Richard P.
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Gobright, E.I.
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Spooner, P.R.
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Allsopp, B.A.
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Sohanpal, B.K.
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Collins, N.
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[Microsequence heterogeneity and expression of LSU rRNA genes within the two single copy ribosomal transcription units of Theileria parva]
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Microsequence heterogeneity and expression of LSU rRNA genes within the two single copy ribosomal transcription units of Theileria parva
Morrison, W. Ivan
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Goddeeris, M.
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Teale, A.J.
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Baldwin, C.L.
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Bensaid, A.M.
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Ellis, J.
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[Cell-mediated immune responses of cattle to Theileria parva]
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Cell-mediated immune responses of cattle to Theileria parva
Theileria parva has been shown to infect and transform B cells and T cells at similar frequencies in vitro. However, the majority of parasitized cells in the tissues of infected cattle are alpha/beta T cells. The aim of this study was to determine whether the cell type infected with T. parva infl...
Morrison, W. Ivan
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MacHugh, Niall D.
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Lalor, P.A.
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[Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite]
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Pathogenicity of Theileria parva is influenced by the host cell type infected by the parasite
Kurtti, T.J.
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Buscher, G.
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Hirumi, H.
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[Establishment and characterization of bovine lymphoblastoid cell lines infected with the intracellular protozoan, Theileria parva]
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Establishment and characterization of bovine lymphoblastoid cell lines infected with the intracellular protozoan, Theileria parva
The polymorphic immunodominant molecule (PIM) of Theileria parva is expressed by the schizont and sporozoite stages of the parasite. We have recently cloned the cDNA encoding the PIM antigen from two stocks of the parasite: the cattle-derived T. parva (Muguga) stock and a buffalo-derived stock. T...
Toye, Philip G.
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Nyanjui, J.
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Goddeeris, B.M.
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Musoke, A.J.
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[Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva]
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Identification of neutralization and diagnostic epitopes on PIM, the polymorphic immunodominant molecule of Theileria parva
Theileria parva, a tick-transmitted protozoan parasite related to Plasmodium spp., causes the disease East Coast fever, an acute and usually fatal lymphoproliferative disorder of cattle in Africa. Previous studies using sera from cattle that have survived infection identified a polymorphic immuno...
Toye, Philip G.
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Metzelaar, M.J.
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Wijngaard, P.L.J.
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Nene, Vishvanath
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Iams, K.P.
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Roose, J.
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Nyanjui, J.K.
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Gobright, E.I.
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Musoke, A.J.
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Clevers, H.C.
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[Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva]
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Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva
Pinder, M.
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Mayor-Withey, K.S.
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Roelants, G.E.
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[Theileria parva parasites transform a subpopulation of T lymphocytes]
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Theileria parva parasites transform a subpopulation of T lymphocytes
There is strong evidence that class I MHC-restricted parasite-specific CD8+ CTL protect cattle against the protozoan parasite Theileria parva. As part of an effort to develop a subunit vaccine for the induction of these responses, we have investigated the factors involved in the generation of T. ...
Compulsory short-interval dipping of cattle for tick control has been enforced in Zimbabwe since the early part of this century. Intensive dipping was initially introduced as a measure to control East Coast fever (ECF), following its introduction from eastern Africa. Dipping was subsequently foun...
Norval, R.A.I.
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Perry, Brian D.
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Hargreaves, S.K.
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[Tick and tick-borne disease control in Zimbabwe: What might the future hold]
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Tick and tick-borne disease control in Zimbabwe: What might the future hold