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Grace, DeliaRandolph, Thomas F.Waibel, H.Diall, O.Clausen, P.H.Kamuanga, M.Affognon, Hippolyte D.[Appraisal of policies to promote socially optimal levels of drug resistance]Appraisal of policies to promote socially optimal levels of drug resistance

In 1986 a project was set up to determine the constraints to production of Zebu cattle under trypanosomiasis risk in the Ghibe valley. Approximately 1800 East African Zebu cattle (EAZC) were resident within the Ghibe valleey during the experimental period (1986 - 1992) and were maintained under t...


Peregrine, A.S.Mulatu, W.Leak, S.G.A.Rowlands, G.J.[Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control]Epidemiology of bovine trypanosomiasis in the Ghibe Valley, Ethiopia: Multiple-drug resistance and its effective control

This paper is a review of the meeting "Sleeping Sickness Rediscovered". The meeting focussed on human sleeping sickness, which, despite improvements in diagnosis and control has returned with a vengeance across central Africa. Topics of discussion include control activities; control tools; resear...


Welburn, S.C.Fèvre, Eric M.Coleman, P.[Sleeping sickness rediscovered]Sleeping sickness rediscovered

In a tsetse-infested area of Kenya, we characterised veterinary-drug outlets based on personnel and business characteristics to assess their capacities to provide clinical veterinary services. Structured questionnaires were administered to the retailers and sought information on the characterist...


Bett, Bernard K.Machila, N.Gathura, P.B.McDermott, John J.Eisler, M.C.[Characterisation of shops selling veterinary medicines in a tsetse-infested area of Kenya]Characterisation of shops selling veterinary medicines in a tsetse-infested area of Kenya

During this century livestock production has increased massively through the improved ability to diagnose, treat, control and prevent certain diseases. Despite these advances, disease remains a major constraint to livestock production and welfare throughout the world. In many instances, this is a...


Gu, Y.Gettinby, G.McKendrick, I.Murray, M.Peregrine, A.S.[Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa]Development of a decision support system for trypanocidal drug control of bovine trypanosomosis in Africa

The relationship between serum concentrations of the prophylactic trypanocidal drug isometamidium chloride and protection against tsetse challenge with two populations of Trypanosoma congolense was investigated in Boran (Bos indicus) cattle, using an isometamidium-ELISA. Isometamidium chloride (S...


Eisler, M.C.Gault, E.A.Moloo, S.K.Holmes, P.H.Peregrine, A.S.[Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense]Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense

Six Boran cattle were infected with the drug-resistant Trypanosoma congolense IL 3338. At the first peak of parasitemia different groups of 200 teneral Glossina morsitans centralis were fed once on each animal, just prior to treatment with diminazene aceturate at a dose of 3.5 mg kg-1 body weight...


Diack, A.Moloo, S.K.Peregrine, A.S.[Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis]Effect of multiple treatment of cattle with diminazene aceturate on the infectivity and transmissibility of drug-resistant Trypanosoma congolense for Glossina morsitans centralis
Kaminsky, R.Gumm, I.D.Chuma, FrancisZweygarth, E.[A drug incubation infectivity test (DIIT) for assessing resistance to trypanosomes]A drug incubation infectivity test (DIIT) for assessing resistance to trypanosomes

A study was carried out to determine whether a drug-resistant trypanosome population could influence the survival of a drug-sensitive population in mixed infections in goats. To identify both populations during the course of a mixed infection, a system for distinguishing them was developed; using...


Burudi, E.M.E.Peregrine, A.S.Majiwa, P.A.O.Mbiuki, S.M.Murphy, N.B.[Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats]Response of diminazene-resistance and diminazene-susceptible Trypanosoma congolense to treatment with diminazene when occuring as a mixed infection in goats

There have been tremendous advances in our knowledge of trypanosome biology, yet many aspects remain unclear. Currently, the genome of Trypanosome brucei is being sequenced and this, with other genome-wide analysis methods, could provide novel insights into the parasite and facilitate the develop...


Agbo, E.C.Majiwa, P.A.O.Bascher, P.Claassen, E.Marinus, F.W.P.[Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets]Trypanosoma brucei genomics and the challenge of identifying drug and vaccine targets

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