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We have previously obtained strong evidence for linkage of mild malaria attack to the MHC region, with a peak close to the tumor necrosis factor (TNF) gene. We screened, for polymorphisms, the entire TNF gene in the same sample of 34 families comprising 197 individuals living in a Plasmodium falc...


Flori, L.Delahaye, N.F.Iraqi, F.A.Hernández Valladares, M.Fumoux, F.Rihet, P.[TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso]TNF as a malaria candidate gene: Polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso

We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatel...


Hernández Valladares, M.Naessens, JanGibson, John P.Musoke, A.J.Nagda, S.M.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Confirmation and dissection of QTL controlling resistance to malaria in mice]Confirmation and dissection of QTL controlling resistance to malaria in mice

The aim of the study was to identify entomological determinants of increased malaria transmission in the vicinity of the Koka reservoir in Central Ethiopia. Larval and adult mosquitoes were collected between August 2006 and December 2007 in villages close to (<1 km) and farther away from (>6 km) ...


Kibret, SolomonLautze, JonathanBoelee, ElineMcCartney, Matthew P.[How does an Ethiopian dam increase malaria?: entomological determinants around the Koka Reservoir.]How does an Ethiopian dam increase malaria?: entomological determinants around the Koka Reservoir.

Susceptible A/J and more resistant C57BL/6J mice were infected with Plasmodium chabaudi chabaudi 54X, P.c. chabaudi AS and Plasmodium chabaudi adami 408XZ. As expected, most C57BL/6J mice survived the infections with the different isolates. But in contrast to previous observations, not all A/J ...


Hernández Valladares, M.Naessens, JanNagda, S.M.Musoke, A.J.Rihet, P.Ole-MoiYoi, O.K.Iraqi, F.A.[Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi]Comparison of pathology in susceptible A/J and resistant C57BL/6J mice after infection with different sub-strains of Plasmodium chabaudi

This study compares the effectiveness and cost-effectiveness of indoor residual house-spraying (IRS) and insecticide-treated bednets (ITNs) against infection with Plasmodium falciparum as part of malaria control in the highlands of western Kenya. Homesteads operationally targeted for IRS and ITNs...


Guyatt, H.L.Corlett, S.K.Robinson, Timothy P.Ochola S.A.Snow, R.W.[Malaria prevention in highland Kenya: Indoor residual house-spraying vs. insecticide-treated bednets]Malaria prevention in highland Kenya: Indoor residual house-spraying vs. insecticide-treated bednets

The development of a sterilizing and cost-effective vaccine against malaria remains a major problem despite recent advances. In this study, it is demonstrated that two antigens of P. falciparum UB05, UB09 and their chimera UB05-09 can serve as protective immunity markers by eliciting higher T-cel...


Dinga, J.N.Njimoh, D.L.Kiawa, B.Djikeng, AppolinaireNyasa, R.B.Nkuo-Akenji, T.Pelle, RogerTitanji, V.P.K.[Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria]Differential T-cell responses to a chimeric Plasmodium falciparum antigen; UB05-09, correlates with acquired immunity to malaria

Identification of the major loci responsible for insecticide resistance in malaria vectors would aid the development andimplementation of effective resistance management strategies, which are urgently needed to tackle the growing threat posedby resistance to the limited insecticides available for...


Witzig, C.Wondji, C.Strode, C.S.Djouaka, R.F.Ranson, H.[Identifying permethrin resistance loci in malaria vectors by genetic mapping]Identifying permethrin resistance loci in malaria vectors by genetic mapping

Aflatoxins, produced by the fungus Aspergillus flavus, are a major health concern because of their acute and chronic health effects on humans and domesticated animals. The Centers for Disease Control (CDC) estimates that more than 4.5 billion people in the developing world are chronically exposed...


Dubois, T.Bandyopadhyay, Ranajit[Aflatoxin control projects launched in southern Africa]Aflatoxin control projects launched in southern Africa

This study compared the efficacy of linguistically and dialectically localized animated educational videos (LAV) against traditional learning extension (TLE) presentations for learning gains of knowledge around agricultural- and healthcare-related topics within a rural population in Benin. While ...


Bello-Bravo, JuliaTamo, M.Dannon, E.A.Pittendrigh, Barry R.[An assessment of learning gains from educational animated videos versus traditional extension presentations among farmers in Benin*]An assessment of learning gains from educational animated videos versus traditional extension presentations among farmers in Benin*

Background: To optimize the success of insecticide-based malaria control intervention, knowledge of the distribution of Anopheles gambiae species and insecticide resistance mechanisms is necessary. This paper reported an updated data on pyrethroids/DDT resistance in the An. gambiae s.l population...


Djegbe, I.Akoton, R.Tchigossou, G.Ahadji-Dabla, K.M.Atoyebi, S.M.Adeoti, R.Zeukeng, F.Ketoh, G.K.Djouaka, R.[First report of the presence of L1014S Knockdown-resistance mutation in Anopheles gambiae s.s and Anopheles coluzzii from Togo, West Africa]First report of the presence of L1014S Knockdown-resistance mutation in Anopheles gambiae s.s and Anopheles coluzzii from Togo, West Africa

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