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Characterising the drug susceptibility of trypanosomes that are pathogenic for domestic livestock has for many years been carried out either in vivo, using large or small animals, or by using various in vitro cultivation methodologies (Peregrine, 1994). Thus, adaptation to, and multiplication of ...


Peregrine, A.S.Wells, C.W.Wilkes, J.M.[Methods for detection of drug resistance in trypanosomes - new developments?]Methods for detection of drug resistance in trypanosomes - new developments?

Trypanosomosis remains one of the biggest impediments to the Development of the livestock industry in sub-Saharan Africa while it is likely that a vaccine for this disease could be found in the future, none is presently available. Mean-while different strategies are being followed to control this...


Majiwa, P.A.O.Konde, V.Souza, M. dePeregrine, A.S.Maina, M.[Molecular approaches to the identification of DNA markers for drug resistance in Trypanosoma congolense]Molecular approaches to the identification of DNA markers for drug resistance in Trypanosoma congolense

Trypanocidal drugs are the most widely applied method of trypanosomosis control in Africa and the only control method in Latin America and Asia . Treatment recommendations and strategies for chemotherapeutic control of trypanosomosis depends on information of trypanosomosis risk and the prevalenc...


Eisler, M.C.McDermott, John J.Mdachi, R.Murilla, G.Sinyangwe, L.Mubanga, J.Machila, N.Mbwambo, H.Coleman, P.G.Clausen, P.H.Bauer, B.Sidibe, I.Geerts, S.Holmes, P.H.Peregrine, A.S.[Rapid method for the assessment of trypanocidal drug resistance in the field]Rapid method for the assessment of trypanocidal drug resistance in the field
Diall, O.Randolph, Thomas F.Clausen, P.H.Waibel, H.Sidibe, I.Schoenefeld, A.Boye, D.Bocoum, Z.Sangare, M.[Detection and control of trypanocide resistance: achievements of the ILRI/BMZ project in the cotton zone of West Africa]Detection and control of trypanocide resistance: achievements of the ILRI/BMZ project in the cotton zone of West Africa

Chemotherapy is the single most important strategy for the control of trypanosomosis in African livestock. Trypanocidal drug resistance is a growing problem across much of sub-Saharan Africa and increasingly recognised as a major threat to livestock production. It is therefore of pressing importa...


Coleman, P.G.Eisler, M.C.McDermott, John J.Murphy, N.B.Majiwa, P.A.O.Peregrine, A.S.[Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense]Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense

There have been numerous Reports of resistance to anthelmintics in Southeast Asia, from Malaysia (Rahman, 1994), Thailand (Kochapakdee et al., 1995) and Indonesia (Dorny et al., 1995). In the Philippines, benzimidazole resistance in a field population of Haemonchus contortus from sheep has been d...


Ancheta, P.B.Dumilon, R.A.Gray, G.D.Villar, E.C.Cerbito, W.A.Ancheta, F.G.[Resistance to benzimidazole anthelmintics in Philippine goats and sheep]Resistance to benzimidazole anthelmintics in Philippine goats and sheep

Tsetse-transmitted trypanosomosis affects cattle production over approximately 10 million km2 of Africa. In these areas, trypanocidal drugs, both prophylactic and curative, are the most widely used methods of trypanosomosis control. However, resistance of trypanosomes to the 3 trypanocidal drugs ...


McDermott, John J.Coleman, P.G.Eisler, M.C.Peregrine, A.S.[The effects of resistance to trypanocidal drugs on trypanosome transmission]The effects of resistance to trypanocidal drugs on trypanosome transmission

In this study, the efficacies of three trypanocidal drugs, diminazene aceturate, isometamidium chloride and homidium bromide, were evaluated in four representative areas of Cote d'Ivoire with different production systems, degree of integration of different trypanosomosis control approaches and de...


D'Ieteren, G.D.M.Coulibaly, L.Atse, P.A.Hecker, P.A.Krebs, H.A.Rowlands, G.J.Leak, S.G.A.Nagda, S.M.[Trypanocidal drug resistance in West Africa]Trypanocidal drug resistance in West Africa

Technical advances in the continuous cultivation of trypanosomes have enabled the Development of in vitro drug screening techniques. Using the mammalian feeder layer cell system for cultivation of infective haematozoic trypomastigotes of Trypanosoma brucei brucei, significant differences in the s...


Waithaka, H.K.Borowy, N.K.Gettinby, G.Scott, J.Hirumi, H.[Trypanocidal drug screening on Trypanosoma (Dutonella) vivax in vitro]Trypanocidal drug screening on Trypanosoma (Dutonella) vivax in vitro

The identification and tracking of sub-populations through time and space are critical to fully understanding the epidemiology of parasitic diseases. However, very little is known about the structure, distribution and dynamics of trypanosome populations in the field. Most laboratory studies that ...


Coleman, P.G.McDermott, John J.[Trypanosome population biology - an approach to support the control of drug resistance and integrated trypanosomosis control]Trypanosome population biology - an approach to support the control of drug resistance and integrated trypanosomosis control

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