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Theileria annulata and Theileria parva both poses a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These anti...


Hall, R.Boulter, N.R.Brown, C.G.D.Wilkie, G.Kirvar, E.Nene, VishvanathMusoke, A.J.Glass, E.J.Morzaria, S.P.[Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva]Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva

Two distinct genes encoding single domain, ATP-binding cassette transport protein homologues of Theileria parva were cloned and sequenced. Neither of the genes is tandemly duplicated. One gene, TpABCI, encodes a predicted protein of 593 amino acids with an N-terminal hydrophobic domain containing...


Kibe, M.K.Macklin, M.D.Gobright, E.I.Bishop, Richard P.Urakawa, T.Ole-MoiYoi, O.K.[Characterisation of single domain ATP-binding cassette protein homologues of Theileria parva]Characterisation of single domain ATP-binding cassette protein homologues of Theileria parva

A first-gneration subunit vaccine for East Coast fever based on the Theileria parva p67 sporozoite surface antigen is entering preliminary field trials. Intensive efforts are also focused on the identification of a schizont-specific omponen for incorporation in a second-generation multi-component...


McKeever, Declan J.Morrison, W. Ivan[Invited review Novel vaccines against Theileria parva: prospects for sustainability]Invited review Novel vaccines against Theileria parva: prospects for sustainability

Full-length recombinant versions of p67, the 709 amino acid major surface protein of Theileria parva sporozoites, induce immunity to East Coast fever (ECF) in cattle. We show that a soluble Escherichia coli recombinant version of p67 (p67635), in which a prokaryotic signal peptide replaces the e...


Bishop, Richard P.Nene, VishvanathStaeyert, J.Rowlands, G.J.Nyanjui, J.Osaso, J.Morzaria, S.P.Musoke, A.J.[Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites]Immunity to East Coast fever in cattle induced by a polypeptide fragment of the major surface coat protein of Theileria parva sporozoites

Two recombinant vaccines against Theileria parva, based on a near full-length version of the sporozoite surface antigen p67 (p67635), or an 80 amino acid C-terminal section (p67C), were evaluated by exposure of immunized cattle to natural tick challenge in two sites at the Kenya Coast and one i...


Musoke, A.J.Rowlands, G.J.Nene, VishvanathNyanjui, J.Katende, J.Spooner, P.R.Mwaura, S.Odongo, D.Nkonge, C.Mbogo, S.Bishop, Richard P.Morzaria, S.P.[Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge]Subunit vaccine based on the p67 major surface protein of Theileria parva sporozoites reduces severity of infection derived from field tick challenge

A clinical trial, comparing East Coast fever (ECF) control strategies in 5 different groups of traditionally managed Sanga cattle (44-49 animals per herd), was conducted in Zambia over 2.5 years between 1992 and 1995. Two groups were kept under intensive tick control by weekly cypermethrin (Barri...


Minjauw, B.Otte, M.J.James, A.D.Castro, J.J. deSinyangwe, P.[Effect of different East Coast Fever control strategies on disease incidence in traditionally managed Sanga cattle in Central Province of Zambia]Effect of different East Coast Fever control strategies on disease incidence in traditionally managed Sanga cattle in Central Province of Zambia
Tetley, L.Vickerman, K.Moloo, S.K.[Absence of a surface coat from metacyclic Trypanosoma vivax. Possible implications for vaccination against vivax trypanosomiasis]Absence of a surface coat from metacyclic Trypanosoma vivax. Possible implications for vaccination against vivax trypanosomiasis
Rumberia, R.M.Rowland, E.Watson, E.D.Eley, R.M.Young, A.S.[The effect of immunization against theileriosis on the reproductive function of Boran/Friesian cross heifers. A preliminary study]The effect of immunization against theileriosis on the reproductive function of Boran/Friesian cross heifers. A preliminary study

Theileria parva (Boleni) stock from Zimbabwe was used to immunise 24 susceptible Friesian calves by infection and treatment with oxytetracycline. Twenty-eight days after immunisation the animals in groups of 6 plus 2 susceptible controls were subjected to challenge: 3 groups with heterologous sto...


Hove, T.Musisi, F.L.Kanhai, G.K.Latif, A.Masaka, S.Munatswa, F.C.Pegram, R.G.Kamwendo, S.P.Quiroga, J.C.Mwangondwe, R.Dolan, T.T.[Challenge of Theileria parva (Boleni) immunised cattle with selected East African Theileria stocks]Challenge of Theileria parva (Boleni) immunised cattle with selected East African Theileria stocks

Rhipicephalus appendiculatus adult ticks, collected int he field from zebu (Bos indicus) and exotic (Bos tarus) cattle with high antibody titres to Theileria parva schizont antigen, transmitted Theileria parva infection typical of East Coast fever to susceptible cattle. Uninfected R. appendiculat...


Kariuki, D.P.Young, A.S.Morzaria, S.P.Lesan, A.C.Mining, S.K.Omwoyo, P.Wafula, J.L.M.Molyneux, D.H.[Theileria parva carrier state in naturally infected and artificially immunized cattle]Theileria parva carrier state in naturally infected and artificially immunized cattle

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