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Under most circumstances, certain breeds of domestic ruminants show a remarkable resistance to the effects of African trypanosomiasis: they can tolerate the presence of parasites while apparently controlling levels of parasitaemia and, crucially, not showing the the severe anaemia and production ...


Kemp, Stephen J.Teale, A.J.[Genetic basis of trypanotolerance in cattle and mice]Genetic basis of trypanotolerance in cattle and mice

Gene-knockout mice have been extensively used in the study of several malaria-induced pathologies. Some investigators believe that the deficient, infected mice mimic disease aspects produced in the absence of the target gene, but others believe that the deficient mice models mainly explain the ef...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Gene-knockout mice in malaria research: Useful or misleading?]Gene-knockout mice in malaria research: Useful or misleading?

Murine models have proved to be excellent tools in the support of studies of the human genetic bases of malaria resistance and have enabled the mapping of 12 resistance loci, eight of them controlling parasitic levels and four controlling cerebral malaria. Further studies using this method have i...


Hernández Valladares, M.Naessens, JanIraqi, F.A.[Genetic resistance to malaria in mouse models]Genetic resistance to malaria in mouse models

The TNF-alfa gene on mouse chromosome MMU17 is among the candidates for the trypanosomosis resistance QTG Tirl. Tit t has the largest effect of those loci so far detected which influence degree of resistance to murine trypanosomosis caused by Trypanosome congolense infection. We therefore studied...


Iraqi, F.A.Sekikawa, K.Rowlands, G.J.Teale, A.J.[Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection]Susceptibility of tumour necrosis factor-alpha genetically deficient mice to Trypanosoma congolense infection

African trypansosomes are tsetse-transmitted parasites of chief importance in causing disease in livestock in regions of sub-Saharan Africa. Previous studies have demonstrated that certain breeds of cattle are relatively resistant to infection with trypanosomes, and others are more susceptible. B...


Haas, K.M.Taylor, K.A.MacHugh, Niall D.Kreeger, J.M.Estes, D.M.[Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection]Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection

Parasitic nematodes are among the most common and economically important infectious diseases of grazing livestock, especially in small ruminants in the tropics and subtropics in Kenya the control of gastrointestinal nematode infections in sheep and goats is usually made with synthetic anthelmin...


Githiori, J.B.Hoglund, J.Waller, P.J.Baker, R.L.[Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice]Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice

Albizia anthelmintica Brong., belongs to the plant family Mimosaceae. The plant is widely used in East Africa by poor smallholder farmers and pastoralists to treat their livestock against internal parasites. The anthelmintic effects of water extracts from the bark of A. anthelmintica, obtained f...


Githiori, J.B.Hoglund, J.Waller, P.J.Baker, R.L.[The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice]The anthelmintic efficacy of the plant, Albizia anthelmintica, against the nematode parasites Haemonchus contortus of sheep and Heligmosomoides polygyrus of mice

Since the publication of the mouse genome, attention has focused on the strains that were selected for sequencing. In this paper we report the results of experiments that characterized the response to infection with the murine gastrointestinal nematode Heligmosomoides polygyrus of eight new strai...


Behnke, J.M.Mugambi, J.M.M.Clifford, S.Iraqi, F.A.Baker, R.L.Gibson, John P.Wakelin, D.[Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project]Genetic variation in resistance to repeated infections with Heligmosomoides polygyrus bakeri, in inbred mouse strains selected for the mouse genome project

Tsetse fly-transmitted trypanosomes (Trypanosoma spp.) cause 'sleeping sickness' in man and have a serious impact on livestock-based agriculture in large areas of Africa. Multigene control of variation in susceptibility to trypanosomiasis is known to occur in mice, where the C57BI/6 (B6) strain i...


Kemp, Stephen J.Iraqi, F.A.Darvasi, A.Soller, M.Teale, A.J.[Localization of genes controlling resistance to trypanosomiasis in mice]Localization of genes controlling resistance to trypanosomiasis in mice

This Doyle Foundation meeting on 'People, mice and livestock.: the story of African trypanosomiasis' was conducted to examine the current status of trypanosomosis in Africa and future research opportunities; and to look at the opportunities for use in the new biosciences platform which has been ...


International Livestock Research Institute[People, mice and livestock. The story of African trypanosomiasis]People, mice and livestock. The story of African trypanosomiasis

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