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Taracha, E.L.N.Goddeeris, M.Scott, J.R.Morrison, W. Ivan[Standardization of a technique for analysing the frequency of parasite-specific cytotoxic T lymphocyte precursors in cattle immunized with Theileria parva]Standardization of a technique for analysing the frequency of parasite-specific cytotoxic T lymphocyte precursors in cattle immunized with Theileria parva

East Coast fever (ECF), caused by Theileria parva, is the most important tick-borne disease of cattle in much of eastern, central and southern Africa. In Kenya, immunization against ECF has been performed in many field trials using the infection and treatment method. The main targets for immuniza...


Deem, S.L.Perry, Brian D.Katende, J.M.McDermott, John J.Mahan, S.M.Maloo, S.H.Morzaria, S.P.Musoke, A.J.Rowlands, G.J.[Variations in prevalence rates of tick-borne diseases in Zebu cattle by agroecological zone: Implications for East Coast fever immunization]Variations in prevalence rates of tick-borne diseases in Zebu cattle by agroecological zone: Implications for East Coast fever immunization

In part I of this review of the prospects of vaccination against African trypanosomiasis, contained in the previous issue of World Animal Review, the constraints in developing a vaccine were discussed and current knowledge on the molecular biology of the trypanosome and on antigenic variation wit...


Murray, M.Barry, J.D.Morrison, W. IvanWilliams, R.O.Hirumi, H.Rovis, L.A.[A review of the prospects for vaccination in African trypanosomiasis. Part II]A review of the prospects for vaccination in African trypanosomiasis. Part II

Immunity to infection by the protozoan parasite Theileria parva in cattle is partially attributable to cytotoxic T cells, which kill lymphocytes infected with the schizont stage of the parasite. Here we evaluated five stocks of buffalo-derived T. parva lawrencei parasites and two stocks of cattle...


Kariuki, T.M.Grootenhuis, J.G.Dolan, T.T.Bishop, Richard P.Baldwin, C.L.[Immunization with Theileria parva parasites from buffaloes results in generation of cytotoxic T cells which recognize antigens common among cells infected with stocks of T. parva parva, T. parva bovis, and T. parva lawrencei]Immunization with Theileria parva parasites from buffaloes results in generation of cytotoxic T cells which recognize antigens common among cells infected with stocks of T. parva parva, T. parva bovis, and T. parva lawrencei

Heterologous priming-boosting vaccination regimens involving priming with plasmid DNA antigen constructs and inoculating (boosting) with the same recombinant antigen expressed in replication-attenuated poxviruses have recently been demonstrated to induce immunity, based on CD4(+)- and CD8(+)-T-c...


Taracha, E.L.N.Bishop, Richard P.Musoke, A.J.Hill, A.V.S.Gilbert, S.C.[Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses]Heterologous priming-boosting immunization of cattle with Mycobacterium tuberculosis 85A induces antigen-specific T-cell responses
Mongi, A.O.Shapiro, S.Z.Doyle, J.J.Cunningham, M.P.[Characterization of antigens from extracts of fed ticks using sera from rabbits immunized with extracted tick antigen and by successive tick infestation]Characterization of antigens from extracts of fed ticks using sera from rabbits immunized with extracted tick antigen and by successive tick infestation
Irvin, A.D.[Potential use of macroschizont infected cells for immunization against Theileria parva]Potential use of macroschizont infected cells for immunization against Theileria parva

Cattle were successfully immunized against heartwater with a lysate of Cowdria ruminantium formulated in Freund's adjuvant. Vaccinated animals proved fully resistant to virulent challenge 3 and 10 months after vaccination. For the first time a helper T lymphocyte response to Cowdria antigens was ...


Totte, P.McKeever, Declan J.Martínez, D.Bensaid, A.[Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium]Analysis of T-cell responses in cattle immunized against heartwater by vaccination with killed elementary bodies of Cowdria ruminantium

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