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Murray, M.Morrison, W. Ivan[Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants]Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei brucei by immunostimulants

Genome-wide quantitative trait locus (QTL) mapping was used to evaluate the genetic basis of resistance to Helgmosomides polygyrus in an F2 cross of SWR and CBA mouse strains that are resistant and susceptible, respectively, to infection. 25 significant QTL affecting at least one of the resistanc...


Menge, D.M.Behnke, J.M.Iraqi, F.A.Lowe, A.Teale, A.J.Gibson, John P.Wakelin, D.Baker, R.L.[Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice]Quantitative trait loci for resistance to gastro-intestinal nematode infections in mice

Chemotherapy is the single most important strategy for the control of trypanosomosis in African livestock. Trypanocidal drug resistance is a growing problem across much of sub-Saharan Africa and increasingly recognised as a major threat to livestock production. It is therefore of pressing importa...


Coleman, P.G.Eisler, M.C.McDermott, John J.Murphy, N.B.Majiwa, P.A.O.Peregrine, A.S.[Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense]Relative fitness in laboratory mice of drug resistant and drug-sensitive field isolates of Trypanosoma congolense

C57BL/6J mice are relatively resistant to trypanosomosis compared to BALB/c or A/J mice. Bloodstream trypanosomes are partly dependent on the host for lipid supply and the plasma lipid levels differ between resistant and susceptible mice. Furthermore, genes controlling plasma lipid levels are dif...


Hassan, M.Agaba, MorrisBulimo, WallaceNoyes, H.Brass, A.Hinsley, T.Iraqi, F.A.Kemp, Stephen J.[Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis]Role of plasma lipids in the susceptibility of laboratory mice to trypanosomosis
Murray, M.Morrison, W. IvanClifford, D.J.Murray, P.K.McIntyre, W.I.M.[Susceptibility to African trypanosomiasis: Studies in cattle and mice]Susceptibility to African trypanosomiasis: Studies in cattle and mice
Morrison, W. IvanRoelants, G.E.Pearson, T.W.Murray, M.[Genetic control of susceptibility to Trypanosoma congolense infections in inbred strains of mice]Genetic control of susceptibility to Trypanosoma congolense infections in inbred strains of mice

Besides the in vitro test, two tests are very commonly used for the detection of trypanocidal drug resistance: the tests in mice and in ruminants. Since it has been shown that several parameters such as the number of trypanosomes inoculated and the time of treatment might influence the outcome of...


Geerts, S.Ndung'u, J.M.Murilla, G.Mbwambo, H.Sirryangwe, L.Machila, N.Delespaux, V.Brandt, J.Peregrine, A.S.McDermott, John J.Holmes, P.H.Eisler, M.C.[In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants]In vivo tests for the detection of resistance to trypanocidal drugs: Tests in mice and in ruminants
Sendashoga, Cyrie N.[Induction, expression and regulation of antibody responses against trypanosoma brucei brucei in mice.]Induction, expression and regulation of antibody responses against trypanosoma brucei brucei in mice.

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