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The characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent wit...
Isometamidium chloride (Samorin, Trypanidium is a phenanthridine-aromatic amidine that is commonly used in cattle as a prophylactic agent against trypanosomiasis. Although the compound has been used for over 30 years, very little is known about its mode of action. Various workers have demonstrate...
This paper determines whether tumour necrosis factor (TNF alpha) (a cytokine that is predominantly secreted by cells of the monocyte/macrophage lineage) production is induced during bovine trypanosomiasis and wheather or not production is correlated with disease. TNF alpha titres in plasma from B...
Techniques for in vivo depletion of lymphocytes using monoclonal antibodies have been well documented for murine systems. This model has played an important role in analysing the involvement of various lymphocyte subsets in several immune mechanisms. In mice 600 ug of Ab are generally injected in...
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