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Rheumatoid arthritis is an autoimmune disease that affects the joints and is characterized by loss of tolerance mechanisms of the immune system, which leads to the activation of a chronic inflammatory immune response against modified self-peptides from the synovium of RA patients, eventually endi...

La artritis reumatoide (AR) es una enfermedad autoinmune que afecta las articulaciones y se caracteriza por una pérdida de los mecanismos de tolerancia, lo que lleva a la activación de una respuesta inflamatoria crónica frente a péptidos propios modificados en el sinovio de los pacientes, derivan...

Oxytocin release within the brain modulates several social behaviours in animals and humans. Moreover, low central oxytocin content has been linked to neuropsychiatric disorders, such as anxiety and autism. The exogenous administration of oxytocin has been proposed for therapeutic treatment, but ...

The methylated cytosine binding protein 2 (MeCP2) is a transcriptional regulator with dual activity, up or down-regulating target genes, acting as a bridge between epigenetic information provided by cytosine methylation and the expression of a given target gene. Interestingly, neuronal activity d...

La proteína de unión a citosinas metiladas 2 (MeCP2) es un regulador transcripcional con actividad dual, activando y reprimiendo genes, actuando de puente entre la información epigenética contenida en la metilación de citosinas y la expresión de genes blanco. La actividad neuronal dirige cambios ...

The neuropeptides oxytocin (OT) and vasopressin (AVP) are key regulators of social and emotional behaviors. Accumulating evidence suggesting a role of OT, AVP, and their receptors in the pathophysiology of psychiatric disorders has sparked interest in these systems as therapeutic targets. Nonethe...

Background: The assessment tools that are most commonly used to evaluate motor behaviour in infants with CP and other similar conditions are focussed mainly on determining the presence or absence of expected motor milestones. Therefore, the “Sensorimotor Performance Scale for Infants between 2-15...

Disrupting the neural activity in the left anterior supramarginal gyrus (SMG) or opercular part of the left inferior frontal gyrus (pOp) with repetitive transcranial magnetic stimulation (TMS) has been demonstrated to cause a transient slowing of response times during phonologically more than sem...

Estudios en las últimas décadas han llevado a la conclusión de que no es la cantidad de grasa presente en un individuo, sino su funcionalidad, lo que determina el desarrollo de consecuencias metabólicas y cardiovasculares por sobrepeso y obesidad. La disfunción del tejido adiposo (TA) lleva a la ...

Studies in recent decades have concluded that it is not the amount of fat present in an individual, but its functionality, which determines the development of metabolic and cardiovascular consequences related with overweight and obesity. Adipose tissue (TA) dysfunction leads to the generation of ...