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Los linfocitos B (LB) son las únicas células del sistema inmune capaces de producir anticuerpos. La activación de LB comienza con el reconocimiento de un antígeno específico en la superficie de una célula presentadora, promoviendo la formación de una región especializada en la membrana plasmática...


Chemotherapy induced peripheral neuropathy (CIPN) is a pathological condition presented as a dose-limiting adverse effect of certain cancer treatments that affects long term quality of life by induction of transient or permanent disability. Chemotherapeutics induce axonal degeneration (AD), intra...

La neuropatía periférica inducida por quimioterapia (CIPN) es una patología que se presenta como un efecto adverso que limita la dosis de ciertos tratamientos anticáncer y afecta la calidad de vida a largo plazo por inducción de discapacidad permanente o transitoria. Las quimioterapias inducen pr...


Las endoxilanasas provenientes de hongos filamentosos mesófilos son enzimas de interés biotecnológico que han sido ampliamente aisladas y caracterizadas. Por el contrario, las endoxilanasas de hongos provenientes de ambientes fríos, como el continente Antártico, han sido menos estudiadas. En esta...

Endoxylanases from mesophilic filamentous fungi are enzymes of biotechnological interest that have been widely isolated and characterized. However, endoxylanases from cold-adapted fungi from environments such as Antarctica have been less studied. This Thesis reports the identification of Cladospo...


Una población del gastrópodo carroñero Nassarius gayi, que habita en un ambiente submareal en Puerto Montt, Décima Región, fue estudiada mensualmente por el período de una año. El objetivo fue establecer el tipo de relación entre actividades fisiológicas, composición bioquímica del complejo gónad...

A population of the scavenger gastropod Nassarius gayi, inhabiting a subtidal environment in Puerto Montt, X Region, Chile, was studied monthly for a period of one year. The objetive was to establish the relationship between physiological activities, biochemical composition of gonad-digestive gla...


Geographic variation is a conspicuous phenomenon in nature and its study is fundamental to understand the causes of the population differentiation of the species. Moreover, such information is critical for species with conservation problems. The "monito del monte" Dromiciops gliroides (Thomas, 18...

La variación geográfica es un fenómeno conspicuo en la naturaleza y su estudio es fundamental para comprender las causas de la diferenciación poblacional de las especies. Por otro lado, dicha información resulta principalmente crítica para especies que presentan problemas de conservación. El “mon...


Circadian rhythms are self-autonomous rhythms generated at cellular level with a period close to 24 hours in constant conditions. They are present in diverse organism, from bacteria to mammals. Although they appear independently throughout evolution, the molecular bases governing them are conserv...


Acidithiobacillus ferrooxidans es la bacteria presente en depósitos de drenajes ácido-mineros más estudiada, ya que juega un papel importante en los procesos de biolixiviación de cobre. Este metal redox en estado libre en la célula es extremadamente tóxico. Por esta razón, los organismos cuentan ...

Acidithiobacillus ferrooxidans is the most studied bacterium in deposits of acid-mining drains, since it plays an important role in copper bioleaching processes. This redox metal free in the cell is extremely toxic. For this reason, organisms have systems to support an increase in its concentrati...


Motion detection is one of the key tasks of the visual systems and has motivated a large body of research. However, the experimental oversimplification has prevented the extrapolation of results to naturalistic and complex situations. On the other hand, it has been proposed that the visual system...


In Chile, Capsicum annuum L. cv. "Cacho de Cabra” berry fruits are used for the manufacture of a traditional chilli powder known as Merkén. The agricultural practices used by Merkén local producers are empirical and do not consider the prevention of mycotoxigenic fungi and, in the last years, myc...

No Chile, o fruto da planta Capsicum annuum L. cv. "Cacho de Cabra” é usado para a produção dum piri-piri em pó chamado Merkén. As práticas usadas pelos produtores locais de Merkén são altamente empíricas e não consideram a prevenção contra fungos micotoxigénicos pelo que, nos últimos anos, conta...


Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval proc...


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