El cáncer de vesícula biliar (CVB) es un tumor maligno con una sobrevida de cinco años inferior al 15%. Mientras que en el mundo se presenta en menos de 2/100.000 individuos, en Chile las tasas de incidencia son superiores a 25 casos por cada 100.000 personas-años en mujeres y 9 casos por cad...
Gallbladder cancer (GBC) is a very aggressive tumor with a five-year survival rate under 15%. Worldwide GBC is considered a rare disease, but in Chile incidence rates amount to 25 cases per 100,000 person-years in women and 9 cases per 100,000 person-years in men. GBC caused 1.316 deaths in Chile...
Las células dendríticas (DCs) han surgido como atractivas candidatas en inmunoterapia del cáncer, debido su alta plasticidad y a su capacidad de regular la inmunidad adaptativa.
Siendo el principal organelo responsable de la síntesis de proteínas, el retículo endoplasmático (RE) es un foco ce...
Dendritic cells (DCs) have emerged as attractive candidates in the cancer immunotherapy field due to their high plasticity and the capacity to regulate adaptive immunity.
As a major organelle responsible of protein synthesis, the endoplasmic reticulum (ER) represents a central hub of the immune...
Introducción y propuesta: La literatura acumulada sugiere que los receptores de acetilcolina nicotínicos (nAChRs) de subtipo α4β2 pueden ser considerados como blancos farmacológicos para el tratamiento de abuso de alcohol. De esta manera, nosotros proponemos que la administración de UFR2709, un n...
Background and Purpose: The accumulated literature suggests that nicotinic acetylcholine receptors (nAChRs) of subtype a4ß2 can be considered as pharmacological targets for the treatment of alcohol abuse. In this way, we propose that the administration of UFR2709, a new competitive antagonist of ...
The reinforcing effect of ethanol is a major contributor to ethanol dependence. The formation of acetaldehyde, the first ethanol metabolite, is required for ethanol to be reinforcing, by activating dopaminergic neurons in the ventral tegmental area (VTA). Whether acetaldehyde can bind to a recept...
El lupus eritematoso sistémico (LES) es una enfermedad autoinmune caracterizada por la activación de linfocitos T y B autorreactivos, producción de autoanticuerpos y deposición de complejos inmunes en varios órganos. Reportes previos muestran una acumulación anormal de linfocitos B en el timo de ...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production and immune complex deposition in several organs. Previous evidence showed an abnormal accumulation of B cells in the thymus of BWF1 diseased mice, a m...
Anosognosia is highly prevalent among people with Alzheimer's disease (AD). This investigation aimed a) to develop and validate a semi-structured interview to assess insight and judgment in patients with AD, and b) to investigate the long-term effect of poor awareness on participants and their ca...
Bacteria growing as biofilms have gained recognition as an important therapeutic challenge due to their relation with the chronicity of infectious diseases. Biofilms are microbial communities that grow within a self-secreted polymeric matrix and represent the predominant growth form of bacteria i...
Las bacterias que crecen como biopelículas han ganado reconocimiento como un desafío terapéutico importante debido a su relación con la cronicidad de las enfermedades infecciosas. Las biopelículas son comunidades microbianas que crecen dentro de una matriz polimérica autosecretada y representan l...
Los fibroblastos cardiacos (CF) son células claves en la mantención de la matriz extracelular (MEC), homeostasis del tejido cardiaco y también en la reparación tisular a través de la diferenciación a miofibroblasto (MFC). Además, los FC cumplen un rol centinela, siendo capaces de responder...
Cardiac fibroblasts (CF) are a key cell for maintaining extracellular matrix (ECM), protein homeostasis in heart tissue and also for cardiac repair through CF-to cardiac myofibroblast (CMF) differentiation. Moreover, CF play a sentinel role in response to mechanical and chemical stimuli by releas...
Se evaluó el efecto protector de un extracto polifenólico de palta rico en proantocianidinas sobre las alteraciones de la homeostasia colónica y la composición de la microbiota intestinal inducidas por una dieta hiperproteica en un biorreactor con microbiota fecal humana y en ratas. El extracto p...
This work evaluates the protective effect of an avocado polyphenolic extract rich in proanthocyanidins on the alterations in the colonic homeostasis and the composition of the intestinal microbiota induced by a high protein diet in a bioreactor with human fecal microbiota and in rats. It was foun...
Breast cancer is the leading cause of cancer-related deaths in women. Although the incidence of this disease has decreased thanks to the implementation of screening mammograms and application of adjuvant therapies, this decrease does not seem to be enough, since the development of metastasis is s...
